CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031256
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plastin-2 
Protein Synonyms/Alias
 cDNA FLJ52759, highly similar to Plastin-2 
Gene Name
 LCP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41ELGKNQAKFSLVGIGacetylation[1]
41ELGKNQAKFSLVGIGubiquitination[1, 2]
111SSSISSFKDPKISTSacetylation[1]
111SSSISSFKDPKISTSubiquitination[1, 2, 3, 4]
148ENLNDDEKLNNAKYAacetylation[1]
148ENLNDDEKLNNAKYAubiquitination[2]
153DEKLNNAKYAISMARubiquitination[1, 2, 5]
179DLVEVNPKMVMTVFAubiquitination[1, 2, 4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 196 AA 
Protein Sequence
MCAEDGDSKF SMSISMNSPF LEILHLENCN YAVELGKNQA KFSLVGIGGQ DLNEGNRTLT 60
LALIWQLMRR YTLNILEEIG GGQKVNDDII VNWVNETLRE AKKSSSISSF KDPKISTSLP 120
VLDLIDAIQP GSINYDLLKT ENLNDDEKLN NAKYAISMAR KIGARVYALP EDLVEVNPKM 180
VMTVFACLMG KGMKRV 196 
Gene Ontology
  
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain. 
Pfam
 PF00307; CH 
SMART
 SM00033; CH 
PROSITE
 PS00020; ACTININ_2
 PS50021; CH 
PRINTS