CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018159
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Huntingtin-interacting protein 1 
Protein Synonyms/Alias
 HIP-1; Huntingtin-interacting protein I; HIP-I 
Gene Name
 Hip1 
Gene Synonyms/Alias
 Kiaa4113 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
46TQTVSVNKAINTQEVubiquitination[1]
118LKDSLRYKNELSDMSubiquitination[1]
155TRMEYHTKNPRFPGNubiquitination[1]
283SSNLQYFKRLIQIPQubiquitination[1]
395TGQLDNMKIESQRAMubiquitination[1]
406QRAMLQLKGRVSELEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. 
Sequence Annotation
 DOMAIN 32 160 ENTH.
 DOMAIN 763 1004 I/LWEQ.
 REGION 410 491 pDED.
 REGION 859 916 Important for actin binding (By
 MOD_RES 154 154 Phosphothreonine.  
Keyword
 Actin-binding; Activator; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Differentiation; Endocytosis; Membrane; Neurodegeneration; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1029 AA 
Protein Sequence
MDRMASSMKQ VSNPLPKVLS RRGVGAGMEA AERESFERTQ TVSVNKAINT QEVAVKEKHA 60
RTCILGTHHE KGAQTFWSVV NRLPLSSNAM LCWKFCHVFH KLLRDGHPNV LKDSLRYKNE 120
LSDMSRMWGH LSEGYGQLCS IYLKLLRTRM EYHTKNPRFP GNLQMSDRQL DEAGESDVNN 180
FFQLTVEMFD YLECELNLFQ TVFNSLDMSR SVSVTTAGQC RLAPLIQVIL DCSHLYDYTV 240
KLLFKLHSCL PADTLQGHRD RFMEQFTKLK DLFQRSSNLQ YFKRLIQIPQ LPENPPNFLR 300
ASALSEHISP VVVIPAEVSS PDSEPVLEKD DLMDMDASQQ TLFDNKFDDV FGSSLSSDPF 360
NFNNQNGVNK DEKDHLIERL YREISGLTGQ LDNMKIESQR AMLQLKGRVS ELEAELAEQQ 420
HLGRQAMDDC EFLRTELDEL KRQREDTEKA QRSLTEIERK AQANEQRYSK LKEKYSELVQ 480
NHADLLRKNA EVTKQVSVAR QAQVDLEREK KELADSFART QEQQDVLENL KHELATSRQE 540
LQVLHSNLET SAQSEAKWLT QIAELEKEQG SLATVAAQRE EELSALRDQL ESTQIKLAGA 600
QESMCQQVKD QRKTLLAGIR KAAEREIQEA LSQLEEPTLI SCAGSTDHLL SKVSSVSSCL 660
EQLEKNGSQY LACPEDISEL LHSITLLAHL TGDTIIQGSA TSLRAPPEPA DSLTEACRQY 720
GRETLAYLSS LEEEGTMENA DVTALRNCLS RVKTLGEELL PRGLDIKQEE LGDLVDKEMA 780
ATSAAIEAAT TRIEEILSKS RAGDTGVKLE VNERILGSCT SLMQAIKVLV VASKDLQKEI 840
VESGRGTASP KEFYAKNSRW TEGLISASKA VGWGATIMVD AADLVVQGKG KFEELMVCSR 900
EIAASTAQLV AASKVKANKG SLNLTQLQQA SRGVNQATAA VVASTISGKS QIEETDSMDF 960
SSMTLTQIKR QEMDSQVRVL ELENDLQKER QKLGELRKKH YELAGVAEGW EEGTEASPST 1020
VQEAIPDKE 1029 
Gene Ontology
 GO:0030136; C:clathrin-coated vesicle; ISO:MGI.
 GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; ISO:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030276; F:clathrin binding; ISO:MGI.
 GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0048268; P:clathrin coat assembly; ISO:MGI.
 GO:0006897; P:endocytosis; IDA:UniProtKB.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011417; ANTH_dom.
 IPR016024; ARM-type_fold.
 IPR008942; ENTH_VHS.
 IPR013809; Epsin-like_N.
 IPR002558; ILWEQ_dom. 
Pfam
 PF07651; ANTH
 PF01608; I_LWEQ 
SMART
 SM00273; ENTH
 SM00307; ILWEQ 
PROSITE
 PS50942; ENTH
 PS50945; I_LWEQ 
PRINTS