UniProt Accession

 SODC_RAT; P07632 

Genbank Protein ID

 Y00404; M25157; X05634; Z21917; Z21918; Z21919; Z21920; BC082800 

Genbank Nucleotide ID

 CAA68465.1; AAA42160.1; CAA29121.1; CAA79925.1; CAA79925.1; CAA79925.1; CAA79925.1; AAH82800.1 

Protein Name

 Superoxide dismutase [Cu-Zn] 

Protein Synonyms/Alias

  

Gene Name

 Sod1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MAMKAVCVLKG	acetylation	[1]
10	MKAVCVLKGDGPVQG	acetylation	[1]
92	LGNVAAGKDGVANVS	acetylation	[1]
123	RTMVVHEKQDDLGKG	acetylation	[1]
129	EKQDDLGKGGNEEST	acetylation	[1]
137	GGNEESTKTGNAGSR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. 

Sequence Annotation

 METAL 47 47 Copper; catalytic (By similarity).
 METAL 49 49 Copper; catalytic (By similarity).
 METAL 64 64 Copper; catalytic (By similarity).
 METAL 64 64 Zinc; structural (By similarity).
 METAL 72 72 Zinc; structural (By similarity).
 METAL 81 81 Zinc; structural (By similarity).
 METAL 84 84 Zinc; structural (By similarity).
 METAL 121 121 Copper; catalytic (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 71 71 N6-acetyllysine (By similarity).
 MOD_RES 99 99 Phosphoserine (By similarity).
 MOD_RES 123 123 N6-acetyllysine (By similarity).
 DISULFID 58 147 By similarity.  

Keyword

 Acetylation; Antioxidant; Complete proteome; Copper; Cytoplasm; Direct protein sequencing; Disulfide bond; Metal-binding; Oxidoreductase; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 154 AA 

Protein Sequence

Gene Ontology

 GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0032839; C:dendrite cytoplasm; ISS:UniProtKB.
 GO:0031012; C:extracellular matrix; ISS:UniProtKB.
 GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0043025; C:neuronal cell body; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005777; C:peroxisome; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0043234; C:protein complex; ISS:UniProtKB.
 GO:0051087; F:chaperone binding; ISS:UniProtKB.
 GO:0005507; F:copper ion binding; ISS:UniProtKB.
 GO:0030346; F:protein phosphatase 2B binding; ISS:UniProtKB.
 GO:0004784; F:superoxide dismutase activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
 GO:0008089; P:anterograde axon cargo transport; IEA:Compara.
 GO:0006309; P:apoptotic DNA fragmentation; ISS:UniProtKB.
 GO:0060088; P:auditory receptor cell stereocilium organization; ISS:UniProtKB.
 GO:0007569; P:cell aging; ISS:UniProtKB.
 GO:0006879; P:cellular iron ion homeostasis; ISS:UniProtKB.
 GO:0006302; P:double-strand break repair; ISS:UniProtKB.
 GO:0007566; P:embryo implantation; ISS:UniProtKB.
 GO:0006749; P:glutathione metabolic process; ISS:UniProtKB.
 GO:0060047; P:heart contraction; ISS:UniProtKB.
 GO:0050665; P:hydrogen peroxide biosynthetic process; ISS:UniProtKB.
 GO:0007626; P:locomotory behavior; ISS:UniProtKB.
 GO:0046716; P:muscle cell homeostasis; ISS:UniProtKB.
 GO:0002262; P:myeloid cell homeostasis; ISS:UniProtKB.
 GO:0045541; P:negative regulation of cholesterol biosynthetic process; ISS:UniProtKB.
 GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
 GO:0060052; P:neurofilament cytoskeleton organization; ISS:UniProtKB.
 GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
 GO:0032287; P:peripheral nervous system myelin maintenance; ISS:UniProtKB.
 GO:0001819; P:positive regulation of cytokine production; ISS:UniProtKB.
 GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
 GO:0051881; P:regulation of mitochondrial membrane potential; ISS:UniProtKB.
 GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
 GO:0060087; P:relaxation of vascular smooth muscle; ISS:UniProtKB.
 GO:0019430; P:removal of superoxide radicals; ISS:UniProtKB.
 GO:0001975; P:response to amphetamine; IEP:RGD.
 GO:0048678; P:response to axon injury; ISS:UniProtKB.
 GO:0046688; P:response to copper ion; IMP:RGD.
 GO:0042493; P:response to drug; ISS:UniProtKB.
 GO:0045471; P:response to ethanol; ISS:UniProtKB.
 GO:0009408; P:response to heat; ISS:UniProtKB.
 GO:0042542; P:response to hydrogen peroxide; ISS:UniProtKB.
 GO:0031667; P:response to nutrient levels; IDA:RGD.
 GO:0001895; P:retina homeostasis; ISS:UniProtKB.
 GO:0008090; P:retrograde axon cargo transport; IEA:Compara.
 GO:0007605; P:sensory perception of sound; ISS:UniProtKB.
 GO:0007283; P:spermatogenesis; ISS:UniProtKB.
 GO:0042554; P:superoxide anion generation; IEA:Compara. 

Interpro

 IPR024134; SOD_Cu/Zn_/chaperones.
 IPR018152; SOD_Cu/Zn_BS.
 IPR001424; SOD_Cu_Zn_dom. 

Pfam

 PF00080; Sod_Cu 

SMART

  

PROSITE

 PS00087; SOD_CU_ZN_1
 PS00332; SOD_CU_ZN_2 

PRINTS

 PR00068; CUZNDISMTASE.