UniProt Accession

 GLRX5_YEAST; Q02784; D6W3V5 

Genbank Protein ID

 U39205; BK006949 

Genbank Nucleotide ID

 AAB68306.1; DAA11371.1 

Protein Name

 Monothiol glutaredoxin-5, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 GRX5 

Gene Synonyms/Alias

 YPL059W; LPE13W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
59	KGTPEFPKCGFSRAT	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Protects cells against oxidative damage due to reactive oxygen species. 

Sequence Annotation

 DOMAIN 35 140 Glutaredoxin.
 REGION 92 96 Glutathione binding (By similarity).
 REGION 117 118 Glutathione binding (By similarity).
 METAL 60 60 Iron-sulfur (2Fe-2S); shared with dimeric
 BINDING 52 52 Glutathione (By similarity).
 BINDING 104 104 Glutathione; via amide nitrogen and  

Keyword

 2Fe-2S; 3D-structure; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Mitochondrion; Redox-active center; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 150 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IDA:SGD.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0015036; F:disulfide oxidoreductase activity; IDA:SGD.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0034599; P:cellular response to oxidative stress; IGI:SGD.
 GO:0016226; P:iron-sulfur cluster assembly; TAS:SGD.
 GO:0006970; P:response to osmotic stress; IMP:SGD. 

Interpro

 IPR002109; Glutaredoxin.
 IPR014434; Monothiol_GRX.
 IPR004480; Monothiol_GRX-rel.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00462; Glutaredoxin 

SMART

  

PROSITE

 PS51354; GLUTAREDOXIN_2 

PRINTS