CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012569
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SCL-interrupting locus protein 
Protein Synonyms/Alias
 TAL-1-interrupting locus protein 
Gene Name
 STIL 
Gene Synonyms/Alias
 SIL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
232SQVQGTYKYGYLTMDubiquitination[1]
954HLLNSSSKETEQPSTubiquitination[1]
1008QLRSLGVKIDSPTKVubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. 
Sequence Annotation
 REGION 584 779 PIN1-binding (By similarity).
 MOD_RES 753 753 Phosphoserine.
 MOD_RES 1135 1135 Phosphoserine.  
Keyword
 Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasm; Developmental protein; Phosphoprotein; Polymorphism; Primary microcephaly; Proto-oncogene; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1287 AA 
Protein Sequence
MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 60
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 120
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 180
LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 240
TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 300
IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 360
NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 420
QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 480
GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 540
VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 600
NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 660
SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 720
DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 780
GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 840
SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNSSLVVRKE PDVPVFFPSG QLAESVSMCL 900
QTGPTGGASN NSETSEEPKI EHVMQPLLHQ PSDNQKIYQD LLGQVNHLLN SSSKETEQPS 960
TKAVIISHEC TRTQNVYHTK KKTHHSRLVD KDCVLNATLK QLRSLGVKID SPTKVKKNAH 1020
NVDHASVLAC ISPEAVISGL NCMSFANVGM SGLSPNGVDL SMEANAIALK YLNENQLSQL 1080
SVTRSNQNNC DPFSLLHINT DRSTVGLSLI SPNNMSFATK KYMKRYGLLQ SSDNSEDEEE 1140
PPDNADSKSE YLLNQNLRSI PEQLGGQKEP SKNDHEIINC SNCESVGTNA DTPVLRNITN 1200
EVLQTKAKQQ LTEKPAFLVK NLKPSPAVNL RTGKAEFTQH PEKENEGDIT IFPESLQPSE 1260
TLKQMNSMNS VGTFLDVKRL RQLPKLF 1287 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0000578; P:embryonic axis specification; ISS:BHF-UCL.
 GO:0033504; P:floor plate development; ISS:BHF-UCL.
 GO:0030900; P:forebrain development; ISS:BHF-UCL.
 GO:0001947; P:heart looping; ISS:BHF-UCL.
 GO:0001701; P:in utero embryonic development; ISS:BHF-UCL.
 GO:0035264; P:multicellular organism growth; ISS:BHF-UCL.
 GO:0043066; P:negative regulation of apoptotic process; ISS:BHF-UCL.
 GO:0001843; P:neural tube closure; ISS:BHF-UCL.
 GO:0030903; P:notochord development; ISS:BHF-UCL.
 GO:0007224; P:smoothened signaling pathway; ISS:BHF-UCL. 
Interpro
 IPR026123; Sil. 
Pfam
  
SMART
  
PROSITE
  
PRINTS