CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014383
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinoic acid-induced protein 1 
Protein Synonyms/Alias
  
Gene Name
 Rai1 
Gene Synonyms/Alias
 Kiaa1820 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1066TTPTPPDKLGGKQRAacetylation[1]
1070PPDKLGGKQRAAFKSacetylation[1]
1122DSPSMPGKDQRSMVLacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 May function as a transcriptional regulator. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. 
Sequence Annotation
 ZN_FING 1838 1885 PHD-type.
 MOTIF 1143 1160 Nuclear localization signal (Potential).
 MOTIF 1206 1223 Nuclear localization signal (Potential).
 MOD_RES 551 551 Phosphoserine (By similarity).
 MOD_RES 666 666 Phosphoserine (By similarity).
 MOD_RES 679 679 Phosphothreonine (By similarity).
 MOD_RES 863 863 Phosphoserine (By similarity).
 MOD_RES 875 875 Phosphoserine (By similarity).
 MOD_RES 1047 1047 Phosphoserine (By similarity).
 MOD_RES 1051 1051 Phosphothreonine (By similarity).
 MOD_RES 1105 1105 Phosphoserine (By similarity).
 MOD_RES 1332 1332 Phosphoserine (By similarity).
 MOD_RES 1343 1343 Phosphoserine (By similarity).
 MOD_RES 1400 1400 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1889 AA 
Protein Sequence
MQSFRERCGF HGKQQNYPQT SQETSRLENY RQPGQAGLSC DRQRLLAKDY YSPQPYTGYE 60
GGTGTPSGTV ATAAADKYHR GSKSLQGRPA FPSYVQDSSP YPGRYSGEEG LQTWGGPQPP 120
PPQPQPLPGA VSKYEENLMK KTVVPPPNRQ YPEQGPQLPF RTHSLHVPPP QPQQPLAYPK 180
LQRQKPQNDL ASPLPFPQGS HFPQHSQSFP TSSTYAPTVQ GGGQGAHSYK SCTAPSAQPH 240
DRPMSANANL APGQRVQNLH AYQPGRLGYE QQQQALQGRH HTQETLHYQN LAKYQHYGQQ 300
GQGYCPPDTA VRTPEQYYQT FSPSSSHSPA RSVGRSPSYS STPSPLMPNL ENFPYSQQPL 360
STGAFPTGIT DHSHFMPLLN PSPTDAASSV DPQAGNCKPL QKEKLPDNLL SDLSLQSLTA 420
LTSQVENISN TVQQLLLSKA TMPQKKGVKN LVSRTPEQHK SQHCSPEGSG YSAEPAGTPL 480
SEPPSSTPQS THAEPQDTDY LSGSEDPLER SFLYCSQARG SPARVNSNSK AKPESVSTCS 540
VTSPDDMSTK SDDSFQSLHS TLPLDSFSKF VAGERDCPRL LLSALAQEDL ASEILGLQEA 600
IVEKADKAWA EASSLPKDNG KPPFSLENHG ACLDTVAKTS WSQPGEPETL PEPLQLDKGG 660
STKDFSPGLF EDPSVAFATT DPKKTSSPLS FGTKPLLGTA TPDPTTAAFD CFPDTPTASS 720
VDGANPFAWP EENLGDACPR WGLHPGELTK GLEQGAKASD GVGKADAHEA SACMGFQEDH 780
AIGKPAAALS GDFKQQEAEG VKEEVGGLLQ CPEVAKANQW LEESRHCCSS TDFGDLPLLP 840
PPGRKEDLEA EEEYSSLCEL LGSPEQRPSL QDPLSPKAPL MCTKEEAEEA LDTKAGWVSP 900
CHLSGEPAVL LGPSVGAQSK VQSWFESSLS HMKPGEEGPE MERAPGSSGT SQGSLAPKPN 960
KPAVPEGPIA KKEPVPRGKS LRSRRVHRGL PEAEDSPCRV PALPKDLLLP ESCTGPPQGQ 1020
AEGAGAPGRG LSEGLPRMCT RSLTALSEPQ TPGPPGLTTT PTPPDKLGGK QRAAFKSGKR 1080
VGKPSPKAAS SPSNPAALPV ASDSSPMGSK TKEPDSPSMP GKDQRSMVLR SRTKPQQVFH 1140
AKRRRPSESR IPDCRATKKL PANNHLPTAY KVSSGPQKEG RMNQRVKVPK PGTGNKLSDR 1200
PLHTLKRKSA FMAPVPAKKR SLILRSNNGS GGDGREERAE SSPGLLRRMA SPQRARPRGS 1260
GEPPPPPPLE PPAACMGLST QSSLPSAVRT KVLPPRKGRG LKLEAIVQKI TSPGLKKLAC 1320
RVAGAPPGTP RSPALPERRP GGSPAGAEEG LGGMGQMLPA ASGADPLCRN PASRSLKGKL 1380
LNSKKLSSAA DCPKAEAFMS PETLPSLGTA RAPKKRSRKG RTGTLGPSKG PLEKRPCPGQ 1440
PLLLAPHDRA SSTQGGGEDN SSGGGKKPKT EELGPASQPP EGRPCQPQTR AQKQPGQASY 1500
SSYSKRKRLS RGRGKTAHAS PCKGRATRRR QQQVLPLDPA EPEIRLKYIS SCKRLRADSR 1560
TPAFSPFVRV EKRDAYTTIC TVVNSPGDEP KPHWKPSSSA ASSSTSSSSL EPAGASLTTF 1620
PGGSVLQQRP SLPLSSTMHL GPVVSKALST SCLVCCLCQN PANFKDLGDL CGPYYPEHCL 1680
PKKKPKLKEK ARLEGTLEEA SLPLERTLKG LECSASTTAA APTTATITTP TALGRLSRPD 1740
GPADPAKQGP LRTSARGLSR RLQSCYCCDG QGDGGEEVAQ ADKSRKHECS KEAPTEPGGD 1800
TQEHWVHEAC AVWTSGVYLV AGKLFGLQEA MKVAVDMPCT SCHEPGATIS CSYKGCIHTY 1860
HYPCANDTGC TFIEENFTLK CPKHKRLPL 1889 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0040015; P:negative regulation of multicellular organism growth; IMP:MGI.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0001501; P:skeletal system development; IMP:MGI. 
Interpro
 IPR001965; Znf_PHD. 
Pfam
  
SMART
 SM00249; PHD 
PROSITE
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS