| Tag | Content |
|---|
| CPLM ID | CPLM-041681 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 5-methyltetrahydrofolate-homocysteine methyltransferase, isoform CRA_b |
Protein Synonyms/Alias | Methionine synthase |
Gene Name | Mtr |
Gene Synonyms/Alias | rCG_30554 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 472 | GEEDFLEKARKIKKF | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | |
Sequence Annotation | REGION 848 849 Cobalamin-binding (By similarity).
REGION 1215 1216 S-adenosyl-L-methionine binding (By
METAL 248 248 Zinc (By similarity).
METAL 311 311 Zinc (By similarity).
METAL 312 312 Zinc (By similarity).
METAL 773 773 Cobalt (cobalamin axial ligand) (By
BINDING 962 962 S-adenosyl-L-methionine (By similarity).
BINDING 1160 1160 S-adenosyl-L-methionine; via carbonyl
BINDING 1164 1164 Cobalamin; via carbonyl oxygen (By |
Keyword | Cobalamin; Cobalt; Complete proteome; Metal-binding; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1253 AA |
Protein Sequence | MKKTLQDEIE AILRKRIMVL DGGMGTMIQR YKLSEENFQG QEFKDHSRPL KGNNDILSIT 60
QPDVIYQIHK EYLLAGADII ETNTFSSTSI AQADYGLEHL AYRMNKCSAD VARKAAEEIT 120
LQTGVKRFVA GSLGPTNKTL SVSPSVERPD YRNITFDELV EAYQEQAKGL LDGGVDILLI 180
ETIFDTANAK AALFALQKLF EENYASPRPI FISGTIVDKS GRTLSGQTGE AFVTSVSHSD 240
PLCIGLNCAL GAAEMRPFIE TIGKCTTAYV LCYPNAGLPN TFGDYDETPA MMAMHLKDFA 300
VDGLVNVVGG CCGSTPDHIR EIAEAVKNCK PRVPPDSVFE GHMLLSGLEP FRIGPYTNFV 360
NIGERCNVAG SKKFAKLIMA GNYEEALSVA KVQVEMGAQV LDINMDDGML DGPSAMTKFC 420
NFIASEPDIA KVPLCIDSSN FAVIEAGLKC CQGKCIVNSI SLKEGEEDFL EKARKIKKFG 480
AAVVVMAFDE EGQATETDVK VSVCTRAYHL LVEKVGFNPN DIIFDPNILT IGTGMEEHNL 540
YAINFIHATR VIKETLPGVR ISGGLSNLSF AFRGMDAIRE AMHGVFLYHA IKFGMDMGIV 600
NAGSLPVYDD IHKDLLQLCE DLIWNRDAEA TEKLLRYAQT HGKGGKKVIQ TDEWRNGSIE 660
ERLEYALVKG IEKHIVEDTE EARLNREKYP RPLNIIEGPL MNGMKVVGDL FGAGKMFLPQ 720
VIKSARVMKK AVGHLIPFME KEREEARVLN GSVEEEDPYQ GTIVLATVKG DVHDIGKNIV 780
GVVLGCNNFR VIDLGVMTPC DKILQAALDH KADIIGLSGL ITPSLDEMIF VAKEMERLAI 840
KIPLLIGGAT TSRTHTAVKI APRYSAPVIH VLDASKSVVV CSQLLDENLK DDYFEEILEE 900
YEDIRQDHYE SLKERKYLPL SQARKHSFHI DWLSEPHPVK PTFIGTQVFE DYNLQKLVDY 960
IDWKPFFDVW QLRGKYPNRG FPKIFNDKAV GEEARKVYED AQNMLNILIS RKKLRARGVV 1020
GFWPAQSVQD DIHLYAEGAV PQAAEPIATF YGLRQQAEKD SSSTDPYHCL SDFVAPLHSG 1080
VRDYLGLFAV ACFGVEELSK AYEDDGDDYS SIMVKALGDR LAEAFAEELH ERVRRELWAY 1140
CGSEQLGVTD LRKLRYEGIR PAPGYPSQPD HTEKLTMWRL ANIEQATGIR LTESLAMAPA 1200
SAVSGLYFSN VKSKYFAVGK ISKDQIEDYA LRKNMSVAEV EKWLGPILGY DTD 1253 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW. GO:0008898; F:homocysteine S-methyltransferase activity; IEA:InterPro. GO:0008705; F:methionine synthase activity; IEA:Compara. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0042558; P:pteridine-containing compound metabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |