UniProt Accession

 ATOX1_HUMAN; O00244; A8KAJ8; D3DQI2; Q2M1R6; Q56AP3 

Genbank Protein ID

 U70660; AY165037; BT009786; AK293063; AY986502; CH471062; CH471062; BC112248; BC112250 

Genbank Nucleotide ID

 AAC51227.1; AAN84554.1; AAP88788.1; BAF85752.1; AAX81411.1; EAW61663.1; EAW61664.1; AAI12249.1; AAI12251.1 

Protein Name

 Copper transport protein ATOX1 

Protein Synonyms/Alias

 Metal transport protein ATX1 

Gene Name

 ATOX1 

Gene Synonyms/Alias

 HAH1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	AVSRVLNKLGGVKYD	ubiquitination	[1, 2]
30	LNKLGGVKYDIDLPN	ubiquitination	[3]
57	TLLATLKKTGKTVSY	acetylation	[4]
60	ATLKKTGKTVSYLGL	acetylation	[4]
60	ATLKKTGKTVSYLGL	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. 

Sequence Annotation

 DOMAIN 2 68 HMA.
 METAL 12 12 Copper.
 METAL 15 15 Copper.  

Keyword

 3D-structure; Chaperone; Complete proteome; Copper; Copper transport; Ion transport; Metal-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 68 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:UniProtKB.
 GO:0016531; F:copper chaperone activity; IDA:UniProtKB.
 GO:0006878; P:cellular copper ion homeostasis; TAS:ProtInc.
 GO:0006825; P:copper ion transport; TAS:UniProtKB.
 GO:0006979; P:response to oxidative stress; TAS:ProtInc. 

Interpro

 IPR017969; Heavy-metal-associated_CS.
 IPR006121; HeavyMe-assoc_HMA. 

Pfam

 PF00403; HMA 

SMART

  

PROSITE

 PS01047; HMA_1
 PS50846; HMA_2 

PRINTS