UniProt Accession

 PAFA2_HUMAN; Q99487; D3DPK1; O15458; Q5SY02 

Genbank Protein ID

 D87845; U89386; AL592064; CH471059; CH471059; BC001158 

Genbank Nucleotide ID

 BAA13468.1; AAC39707.1; CAI10970.1; EAX07852.1; EAX07853.1; AAH01158.1 

Protein Name

 Platelet-activating factor acetylhydrolase 2, cytoplasmic 

Protein Synonyms/Alias

 Serine-dependent phospholipase A2; SD-PLA2; hSD-PLA2 

Gene Name

 PAFAH2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
148	AATTYFCKQAPEENQ	ubiquitination	[1]
176	RRVEEGEKEFHVRNP	acetylation	[2]
176	RRVEEGEKEFHVRNP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme. 

Sequence Annotation

 ACT_SITE 236 236 Nucleophile (By similarity).
 ACT_SITE 259 259 Charge relay system (By similarity).
 ACT_SITE 314 314 Charge relay system (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003847; F:1-alkyl-2-acetylglycerophosphocholine esterase activity; IEA:EC.
 GO:0005543; F:phospholipid binding; TAS:ProtInc.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0006629; P:lipid metabolic process; TAS:ProtInc.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara. 

Interpro

 IPR016715; Ac_Ohase_PAF.
 IPR005065; PAF_acetylhydro. 

Pfam

 PF03403; PAF-AH_p_II 

SMART

  

PROSITE

 PS00120; LIPASE_SER 

PRINTS