UniProt Accession

 SLK_MOUSE; O54988; A2RRK4; Q80U65; Q8CAU2; Q8CDW2; Q9WU41 

Genbank Protein ID

 AF039574; AF112855; AK037798; AK122218; BC131675; AK029491 

Genbank Nucleotide ID

 AAB96682.1; AAD28717.1; BAC29874.1; BAC65500.1; AAI31676.1; BAC26474.1 

Protein Name

 STE20-like serine/threonine-protein kinase 

Protein Synonyms/Alias

 STE20-like kinase; mSLK; Etk4; STE20-related kinase SMAK; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2 

Gene Name

 Slk 

Gene Synonyms/Alias

 Kiaa0204; Stk2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
298	FVTVDSNKPVRELIA	ubiquitination	[1]
464	ETNTDCLKPEEDRNK	acetylation	[2]
1104	DQDREKIKQFAAQEE	ubiquitination	[1]
1185	EKLRPRKKTLEEEFA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Mediates apoptosis and actin stress fiber dissolution. 

Sequence Annotation

 DOMAIN 34 292 Protein kinase.
 DOMAIN 873 908 UVR.
 NP_BIND 40 48 ATP (By similarity).
 ACT_SITE 155 155 Proton acceptor (By similarity).
 BINDING 63 63 ATP (By similarity).
 MOD_RES 181 181 Phosphothreonine (By similarity).
 MOD_RES 189 189 Phosphoserine.
 MOD_RES 340 340 Phosphoserine (By similarity).
 MOD_RES 341 341 Phosphoserine (By similarity).
 MOD_RES 344 344 Phosphoserine (By similarity).
 MOD_RES 347 347 Phosphoserine (By similarity).
 MOD_RES 348 348 Phosphoserine.
 MOD_RES 354 354 Phosphoserine.
 MOD_RES 370 370 Phosphoserine (By similarity).
 MOD_RES 542 542 Phosphoserine (By similarity).
 MOD_RES 543 543 Phosphoserine.
 MOD_RES 561 561 Phosphoserine (By similarity).
 MOD_RES 566 566 Phosphoserine (By similarity).
 MOD_RES 753 753 Phosphothreonine (By similarity).
 MOD_RES 770 770 Phosphoserine (By similarity).
 MOD_RES 775 775 Phosphoserine (By similarity).
 MOD_RES 777 777 Phosphoserine.
 MOD_RES 812 812 Phosphothreonine (By similarity).
 MOD_RES 816 816 Phosphoserine (By similarity).
 MOD_RES 1095 1095 Phosphothreonine (By similarity).
 MOD_RES 1233 1233 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Apoptosis; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1233 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR022165; PKK.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR001943; UVR_dom. 

Pfam

 PF00069; Pkinase
 PF12474; PKK 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50151; UVR 

PRINTS