CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021408
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CUB domain-containing protein 1 
Protein Synonyms/Alias
 Membrane glycoprotein gp140; Subtractive immunization M plus HEp3-associated 135 kDa protein; SIMA135; Transmembrane and associated with src kinases; CD318 
Gene Name
 CDCP1 
Gene Synonyms/Alias
 TRASK; UNQ2486/PRO5773 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
71HITMLSIKSGERIVFubiquitination[1]
296TTNPEVFKLEDKQPGubiquitination[1, 2]
343HPQNESNKIYVVDLSubiquitination[1]
542VSFIPYFKEEGVFTVubiquitination[1]
554FTVTPDTKSKVYLRTubiquitination[1, 2]
700KKKKKTNKGPAVGIYubiquitination[1]
787CSRAPTAKLATEEPPubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. 
Sequence Annotation
 DOMAIN 417 544 CUB.
 MOD_RES 707 707 Phosphotyrosine.
 MOD_RES 734 734 Phosphotyrosine.
 CARBOHYD 39 39 N-linked (GlcNAc...) (Potential).
 CARBOHYD 122 122 N-linked (GlcNAc...) (Potential).
 CARBOHYD 180 180 N-linked (GlcNAc...) (Potential).
 CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).
 CARBOHYD 270 270 N-linked (GlcNAc...) (Potential).
 CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).
 CARBOHYD 386 386 N-linked (GlcNAc...) (Potential).
 DISULFID 476 499 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 836 AA 
Protein Sequence
MAGLNCGVSI ALLGVLLLGA ARLPRGAEAF EIALPRESNI TVLIKLGTPT LLAKPCYIVI 60
SKRHITMLSI KSGERIVFTF SCQSPENHFV IEIQKNIDCM SGPCPFGEVQ LQPSTSLLPT 120
LNRTFIWDVK AHKSIGLELQ FSIPRLRQIG PGESCPDGVT HSISGRIDAT VVRIGTFCSN 180
GTVSRIKMQE GVKMALHLPW FHPRNVSGFS IANRSSIKRL CIIESVFEGE GSATLMSANY 240
PEGFPEDELM TWQFVVPAHL RASVSFLNFN LSNCERKEER VEYYIPGSTT NPEVFKLEDK 300
QPGNMAGNFN LSLQGCDQDA QSPGILRLQF QVLVQHPQNE SNKIYVVDLS NERAMSLTIE 360
PRPVKQSRKF VPGCFVCLES RTCSSNLTLT SGSKHKISFL CDDLTRLWMN VEKTISCTDH 420
RYCQRKSYSL QVPSDILHLP VELHDFSWKL LVPKDRLSLV LVPAQKLQQH THEKPCNTSF 480
SYLVASAIPS QDLYFGSFCP GGSIKQIQVK QNISVTLRTF APSFQQEASR QGLTVSFIPY 540
FKEEGVFTVT PDTKSKVYLR TPNWDRGLPS LTSVSWNISV PRDQVACLTF FKERSGVVCQ 600
TGRAFMIIQE QRTRAEEIFS LDEDVLPKPS FHHHSFWVNI SNCSPTSGKQ LDLLFSVTLT 660
PRTVDLTVIL IAAVGGGVLL LSALGLIICC VKKKKKKTNK GPAVGIYNDN INTEMPRQPK 720
KFQKGRKDND SHVYAVIEDT MVYGHLLQDS SGSFLQPEVD TYRPFQGTMG VCPPSPPTIC 780
SRAPTAKLAT EEPPPRSPPE SESEPYTFSH PNNGDVSSKD TDIPLLNTQE PMEPAE 836 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. 
Interpro
 IPR000859; CUB_dom. 
Pfam
  
SMART
  
PROSITE
 PS01180; CUB 
PRINTS