| Tag | Content |
|---|
| CPLM ID | CPLM-008462 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Squalene monooxygenase |
Protein Synonyms/Alias | Squalene epoxidase; SE |
Gene Name | Sqle |
Gene Synonyms/Alias | Erg1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 288 | VADGLFSKFRKSLIS | ubiquitination | [1] | | 424 | GGMTVALKDIKLWRQ | ubiquitination | [1] | | 434 | KLWRQLLKDIPDLYD | ubiquitination | [1] | | 449 | DAAIFQAKKSFFWSR | ubiquitination | [1] | | 450 | AAIFQAKKSFFWSRK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. |
Sequence Annotation | NP_BIND 124 151 FAD (Potential). |
Keyword | Complete proteome; Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Microsome; NADP; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 572 AA |
Protein Sequence | MWTFLGIATF TYFYKKCGDV TLANKELLLC VLVFLSLGLV LSYRCRHRHG GLLGRHQSGA 60
QFAAFSDILS ALPLIGFFWA KSPESEKKEQ LESKKCRKEI GLSETTLTGA ATSVSTSFVT 120
DPEVIIVGSG VLGSALAAVL SRDGRKVTVI ERDLKEPDRI VGELLQPGGY RVLQELGLGD 180
TVEGLNAHHI HGYIVHDYES RSEVQIPYPL SETNQVQSGI AFHHGRFIMS LRKAAMAEPN 240
VKFIEGVVLQ LLEEDDAVIG VQYKDKETGD TKELHAPLTV VADGLFSKFR KSLISSKVSV 300
SSHFVGFLMK DAPQFKPNFA ELVLVNPSPV LIYQISSSET RVLVDIRGEL PRNLREYMAE 360
QIYPQLPEHL KESFLEASQN GRLRTMPASF LPPSSVNKRG VLILGDAYNL RHPLTGGGMT 420
VALKDIKLWR QLLKDIPDLY DDAAIFQAKK SFFWSRKRTH SFVVNVLAQA LYELFSATDD 480
SLHQLRKACF LYFKLGGECV TGPVGLLSIL SPHPLVLIRH FFSVAIYATY FCFKSEPWAT 540
KPRALFSSGA VLYKACSILF PLIYSEMKYL VH 572 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. GO:0004506; F:squalene monooxygenase activity; IEA:EC. GO:0006725; P:cellular aromatic compound metabolic process; IEA:Compara. GO:0008203; P:cholesterol metabolic process; IEA:Compara. GO:0010033; P:response to organic substance; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |