CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016318
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Extracellular matrix protein FRAS1 
Protein Synonyms/Alias
  
Gene Name
 FRAS1 
Gene Synonyms/Alias
 KIAA1500 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
3951EEYPLNTKVEVPKRHubiquitination[1]
3989PEAAYTFKGAKVKRLubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
 DOMAIN 27 88 VWFC 1.
 DOMAIN 93 153 VWFC 2.
 DOMAIN 157 217 VWFC 3.
 DOMAIN 219 279 VWFC 4.
 DOMAIN 283 343 VWFC 5.
 DOMAIN 347 417 VWFC 6.
 REPEAT 409 460 FU 1.
 REPEAT 462 505 FU 2.
 REPEAT 507 553 FU 3.
 REPEAT 555 599 FU 4.
 REPEAT 602 647 FU 5.
 REPEAT 649 705 FU 6.
 REPEAT 708 753 FU 7.
 REPEAT 755 800 FU 8.
 REPEAT 803 852 FU 9.
 REPEAT 854 900 FU 10.
 REPEAT 903 948 FU 11.
 REPEAT 952 997 FU 12.
 REPEAT 999 1042 FU 13.
 REPEAT 1046 1089 FU 14.
 REPEAT 1090 1201 CSPG 1.
 REPEAT 1202 1310 CSPG 2.
 REPEAT 1311 1445 CSPG 3.
 REPEAT 1446 1574 CSPG 4.
 REPEAT 1575 1691 CSPG 5.
 REPEAT 1692 1821 CSPG 6.
 REPEAT 1822 1939 CSPG 7.
 REPEAT 1940 2059 CSPG 8.
 REPEAT 2060 2178 CSPG 9.
 REPEAT 2179 2293 CSPG 10.
 REPEAT 2294 2415 CSPG 11.
 REPEAT 2418 2542 CSPG 12.
 DOMAIN 2543 2646 Calx-beta 1.
 DOMAIN 2659 2770 Calx-beta 2.
 DOMAIN 2784 2890 Calx-beta 3.
 DOMAIN 2905 3007 Calx-beta 4.
 DOMAIN 3025 3129 Calx-beta 5.
 MOD_RES 344 344 Phosphoserine.
 CARBOHYD 361 361 N-linked (GlcNAc...) (Potential).
 CARBOHYD 728 728 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1093 1093 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1108 1108 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1504 1504 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1777 1777 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1948 1948 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1978 1978 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2563 2563 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2664 2664 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2682 2682 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2908 2908 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2985 2985 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3070 3070 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3218 3218 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3676 3676 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3875 3875 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Calcium; Cell membrane; Complete proteome; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4008 AA 
Protein Sequence
MGVLKVWLGL ALALAEFAVL PHHSEGACVY QDSLLADATI WKPDSCQSCR CHGDIVICKP 60
AVCRNPQCAF EKGEVLQIAA NQCCPECVLR TPGSCHHEKK IHEHGTEWAS SPCSVCSCNH 120
GEVRCTPQPC PPLSCGHQEL AFIPEGSCCP VCVGLGKPCS YEGHVFQDGE DWRLSRCAKC 180
LCRNGVAQCF TAQCQPLFCN QDETVVRVPG KCCPQCSARS CSAAGQVYEH GEQWSENACT 240
TCICDRGEVR CHKQACLPLR CGKGQSRARR HGQCCEECVS PAGSCSYDGV VRYQDEMWKG 300
SACEFCMCDH GQVTCQTGEC AKVECARDEE LIHLDGKCCP ECISRNGYCV YEETGEFMSS 360
NASEVKRIPE GEKWEDGPCK VCECRGAQVT CYEPSCPPCP VGTLALEVKG QCCPDCTSVH 420
CHPDCLTCSQ SPDHCDLCQD PTKLLQNGWC VHSCGLGFYQ AGSLCLACQP QCSTCTSGLE 480
CSSCQPPLLM RHGQCVPTCG DGFYQDRHSC AVCHESCAGC WGPTEKHCLA CRDPLHVLRD 540
GGCESSCGKG FYNRQGTCSA CDQSCDSCGP SSPRCLTCTE KTVLHDGKCM SECPGGYYAD 600
ATGRCKVCHN SCASCSGPTP SHCTACSPPK ALRQGHCLPR CGEGFYSDHG VCKACHSSCL 660
ACMGPAPSHC TGCKKPEEGL QVEQLSDVGI PSGECLAQCR AHFYLESTGI CEACHQSCFR 720
CAGKSPHNCT DCGPSHVLLD GQCLSQCPDG YFHQEGSCTE CHPTCRQCHG PLESDCISCY 780
PHISLTNGNC RTSCREEQFL NLVGYCADCH HLCQHCAADL HNTGSICLRC QNAHYLLLGD 840
HCVPDCPSGY YAERGACKKC HSSCRTCQGR GPFSCSSCDT NLVLSHTGTC STTCFPGHYL 900
DDNHVCQPCN THCGSCDSQA SCTSCRDPNK VLLFGECQYE SCAPQYYLDF STNTCKECDW 960
SCSACSGPLK TDCLQCMDGY VLQDGACVEQ CLSSFYQDSG LCKNCDSYCL QCQGPHECTR 1020
CKGPFLLLEA QCVQECGKGY FADHAKHKCT ACPQGCLQCS HRDRCHLCDH GFFLKSGLCV 1080
YNCVPGFSVH TSNETCSGKI HTPSLHVNGS LILPIGSIKP LDFSLLNVQD QEGRVEDLLF 1140
HVVSTPTNGQ LVLSRNGKEV QLDKAGRFSW KDVNEKKVRF VHSKEKLRKG YLFLKISDQQ 1200
FFSEPQLINI QAFSTQAPYV LRNEVLHISR GERATITTQM LDIRDDDNPQ DVVIEIIDPP 1260
LHGQLLQTLQ SPATPIYQFQ LDELSRGLLH YAHDGSDSTS DVAVLQANDG HSFHNILFQV 1320
KTVPQNDRGL QLVANSMVWV PEGGMLQITN RILQAEAPGA SAEEIIYKIT QDYPQFGEVV 1380
LLVNMPADSP ADEGQHLPDG RTATPTSTFT QQDINEGIVW YRHSGAPAQS DSFRFEVSSA 1440
SNAQTRLESH MFNIAILPQT PEAPKVSLEA SLHMTAREDG LTVIQPHSLS FINSEKPSGK 1500
IVYNITLPLH PNQGIIEHRD HPHSPIRYFT QEDINQGKVM YRPPPAAPHL QELMAFSFAG 1560
LPESVKFHFT VSDGEHTSPE MVLTIHLLPS DQQLPVFQVT APRLAVSPGG STSVGLQVVV 1620
RDAETAPKEL FFELRRPPQH GVLLKHTAEF RRPMATGDTF TYEDVEKNAL QYIHDGSSTR 1680
EDSMEISVTD GLTVTMLEVR VEVSLSEDRG PRLAAGSSLS ITVASKSTAI ITRSHLAYVD 1740
DSSPDPEIWI QLNYLPSYGT LLRISGSEVE ELSEVSNFTM EDINNKKIRY SAVFETDGHL 1800
VTDSFYFSVS DMDHNHLDNQ IFTIMITPAE NPPPVIAFAD LITVDEGGRA PLSFHHFFAT 1860
DDDDNLQRDA IIKLSALPKY GCIENTGTGD RFGPETASDL EASFPIQDVL ENYIYYFQSV 1920
HESIEPTHDI FSFYVSDGTS RSEIHSINIT IERKNDEPPR MTLQPLRVQL SSGVVISNSS 1980
LSLQDLDTPD NELIFVLTKK PDHGHVLWRQ TASEPLENGR VLVQGSTFTY QDILAGLVGY 2040
VPSVPGMVVD EFQFSLTDGL HVDTGRMKIY TELPASDTPH LAINQGLQLS AGSVARITEQ 2100
HLKVTDIDSD DHQVMYIMKE DPGAGRLQMM KHGNLEQISI KGPIRSFTQA DISQGHVEYS 2160
HGTGEPGGSF AFKFDVVDGE GNRLIDKSFS ISILEDKSPP VITTNKGLVL DENSVKKITT 2220
LQLSATDQDS GPTELIYRIT RQPQLGHLEH AASPGIQISS FTQADLTSRN VQYVHSSEAE 2280
KHSDAFSFTL SDGVSEVTQT FHITLHPVDD SLPVVQNLGM RVQEGMRKTI TEFELKAVDA 2340
DTEAESVTFT IVQPPRHGTI ERTSNGQHFH LTSTFTMKDI YQNRVSYSHD GSNSLKDRFT 2400
FTVSDGTNPF FIIEEGGKEI MTAAPQPFRV DILPVDDGTP RIVTNLGLQW LEYMDGKATN 2460
LITKKELLTM DPDTEDAQLV YEITTGPKHG FVENKLQPGR AAATFTQEDV NLGLIRYVLH 2520
KEKIREMMDS FQFLVKDSKP NVVSDNVFHI QWSLISFKYT SYNVSEKAGS VSVTVQRTGN 2580
LNQYAIVLCR TEQGTASSSS RVSSQPGQQD YVEYAGQVQF DEREDTKSCT IVINDDDVFE 2640
NVESFTVELS MPAYALLGEF TQAKVIINDT EDEPTLEFDK KIYWVNESAG FLFAPIERKG 2700
DASSIVSAIC YTVPKSAMGS SLYALESGSD FKSRGMSAAS RVIFGPGVTM STCDVMLIDD 2760
SEYEEEEEFE IALADASDNA RIGRVATAKV LISGPNDAST VSLGNTAFTV SEDAGTVKIP 2820
VIRHGTDLST FASVWCATRP SDPASATPGV DYVPSSRKVE FGPGVIEQYC TLTILDDTQY 2880
PVIEGLETFV VFLSSAQGAE LTKPFQAVIA INDTFQDVPS MQFAKDLLLV KEKEGVLHVP 2940
ITRSGDLSYE SSVRCYTQSH SAQVMEDFEE RQNADSSRIT FLKGDKVKNC TVYIHDDSMF 3000
EPEEQFRVYL GLPLGNHWSG ARIGKNNMAT ITISNDEDAP TIEFEEAAYQ VREPAGPDAI 3060
AILNIKVIRR GDQNRTSKVR CSTRDGSAQS GVDYYPKSRV LKFSPGVDHI FFKVEILSNE 3120
DREWHESFSL VLGPDDPVEA VLGDVTTATV TILDQEAAGS LILPAPPIVV TLADYDHVEE 3180
VTKEGVKKSP SPGYPLVCVT PCDPHFPRYA VMKERCSEAG INQTSVQFSW EVAAPTDGNG 3240
ARSPFETITD NTPFTSVNHM VLDSIYFSRR FHVRCVAKAV DKVGHVGTPL RSNIVTIGTD 3300
SAICHTPVVA GTSRGFQAQS FIATLKYLDV KHKEHPNRIH ISVQIPHQDG MLPLISTMPL 3360
HNLHFLLSES IYRHQHVCSN LVTTYDLRGI SEAGFLDDVV YDSTALGPGY DRPFQFDPSV 3420
REPKTIQLYK HLNLKSCVWT FDAYYDMTEL IDVCGGSVTA DFQVRDSAQS FLTVHVPLYV 3480
SYIYVTAPRG WASLEHHTEM EFSFFYDTVL WRTGIQTDSV LSARLQIIRI YIREDGRLVI 3540
EFKTHAKFRG QFVMEHHTLP EVKSFVLTPD HLGGIEFDLQ LLWSAQTFDS PHQLWRATSS 3600
YNRKDYSGEY TIYLIPCTVQ PTQPWVDPGE KPLACTAHAP ERFLIPIAFQ QTNRPVPVVY 3660
SLNTEFQLCN NEKVFLMDPN TSDMSLAEMD YKGAFSKGQI LYGRVLWNPE QNLNSAYKLQ 3720
LEKVYLCTGK DGYVPFFDPT GTIYNEGPQY GCIQPNKHLK HRFLLLDRNQ PEVTDKYFHD 3780
VPFEAHFASE LPDFHVVSNM PGVDGFTLKV DALYKVEAGH QWYLQVIYII GPDTISGPRV 3840
QRSLTAPLRR NRRDLVEPDG QLILDDSLIY DNEGDQVKNG TNMKSLNLEM QELAVAASLS 3900
QTGASIGSAL AAIMLLLLVF LVACFINRKC QKQRKKKPAE DILEEYPLNT KVEVPKRHPD 3960
RVEKNVNRHY CTVRNVNILS EPEAAYTFKG AKVKRLNLEV RVHNNLQDGT EV 4012 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007154; P:cell communication; IEA:InterPro. 
Interpro
 IPR003644; Calx_beta.
 IPR000742; EG-like_dom.
 IPR006212; Furin_repeat.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR001007; VWF_C. 
Pfam
 PF03160; Calx-beta
 PF00093; VWC 
SMART
 SM00237; Calx_beta
 SM00181; EGF
 SM00261; FU
 SM00214; VWC 
PROSITE
 PS01208; VWFC_1
 PS50184; VWFC_2 
PRINTS