UniProt Accession

 SESN1_HUMAN; Q9Y6P5; Q2M2B7; Q5T316; Q9NV00; Q9UPD5; Q9Y6P6 

Genbank Protein ID

 AF033122; AF033120; AF033121; AL390208; CH471051; CH471051; BC112036; BC113569; AK001886 

Genbank Nucleotide ID

 AAD04812.1; AAD04810.1; AAD04811.1; CAI16720.1; EAW48367.1; EAW48368.1; AAI12037.1; AAI13570.1; BAA91961.1 

Protein Name

 Sestrin-1 

Protein Synonyms/Alias

 p53-regulated protein PA26 

Gene Name

 SESN1 

Gene Synonyms/Alias

 PA26; SEST1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
337	EDTSYGYKDFSRHGM	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth. 

Sequence Annotation

 MOD_RES 293 293 Phosphoserine.
 MOD_RES 314 314 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 492 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0007050; P:cell cycle arrest; TAS:ProtInc.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0006974; P:response to DNA damage stimulus; TAS:ProtInc. 

Interpro

 IPR006730; PA26. 

Pfam

 PF04636; PA26 

SMART

  

PROSITE

  

PRINTS