CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016185
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone-lysine N-methyltransferase setd3 
Protein Synonyms/Alias
 SET domain-containing protein 3 
Gene Name
 SETD3 
Gene Synonyms/Alias
 C14orf154 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23ATATVSPKEILNLTSubiquitination[1]
74LSVTFDGKREDYFPDubiquitination[1]
466VRAKMAIKLRLGEKEubiquitination[1]
477GEKEILEKAVKSAAVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). 
Sequence Annotation
 DOMAIN 94 314 SET.
 MOD_RES 14 14 Phosphothreonine (By similarity).
 MOD_RES 513 513 Phosphoserine.  
Keyword
 3D-structure; Activator; Alternative splicing; Chromatin regulator; Complete proteome; Methyltransferase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 594 AA 
Protein Sequence
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PGPGKEWEEY VQIRTLVEKI 60
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF 120
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP 180
SEYDTPLYFE EDEVRYLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKDSFT 240
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL 300
QDFRAGEQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA 360
GIPTSSVFAL HFTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNSEFPVSW 420
DNEVKLWTFL EDRASLLLKT YKTTIEEDKS VLKNHDLSVR AKMAIKLRLG EKEILEKAVK 480
SAAVNREYYR QQMEEKAPLP KYEESNLGLL ESSVGDSRLP LVLRNLEEEA GVQDALNIRE 540
AISKAKATEN GLVNGENSIP NGTRSENESL NQESKRAVED AKGSSSDSTA GVKE 594 
Gene Ontology
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB.
 GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IEA:Compara.
 GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
 GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.
 GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
 GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB.
 GO:0051149; P:positive regulation of muscle cell differentiation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR025785; Hist-Lys_N-MeTrfase_SETD3.
 IPR015353; Rubisco_LSMT_subst-bd.
 IPR001214; SET_dom. 
Pfam
 PF09273; Rubis-subs-bind
 PF00856; SET 
SMART
  
PROSITE
 PS51565; SAM_MT43_SETD3
 PS50280; SET 
PRINTS