UniProt Accession

 NXSA_PSSEM; P60775; P01435 

Genbank Protein ID

 X02533; AB017932; AB098526; AB098527 

Genbank Nucleotide ID

 CAA26373.1; BAA75752.1; BAC78199.1; BAC78200.1 

Protein Name

 Erabutoxin a 

Protein Synonyms/Alias

 Short neurotoxin 1a 

Gene Name

 ETXA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Pseudolaticauda semifasciata (Black-banded sea krait) (Laticaud 

NCBI Taxa ID

 8631 

Lysine Modification

Position	Peptide	Type	References
48	GESSCYNKQWSDFRG	acetylation	[1]
68	GCGCPTVKPGIKLSC	acetylation	[1]

Reference

 [1] Molecular conformation and function of erabutoxins as studied by nuclear magnetic resonance.
 Inagaki F, Tamiya N, Miyazawa T.
 Eur J Biochem. 1980 Aug;109(1):129-38. [PMID: 6773770] 

Functional Description

 Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Blocks the extracellular increase of dopamine evoked by nicotine at 4.2 uM concentrations. 

Sequence Annotation

 DISULFID 24 45
 DISULFID 38 62
 DISULFID 64 75
 DISULFID 76 81  

Keyword

 3D-structure; Acetylcholine receptor inhibiting toxin; Direct protein sequencing; Disulfide bond; Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted; Signal; Toxin. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 83 AA 

Protein Sequence

Gene Ontology

 GO:0035792; C:other organism postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0035821; P:modification of morphology or physiology of other organism; IEA:InterPro. 

Interpro

 IPR003571; Snake_toxin.
 IPR018354; Snake_toxin_BS. 

Pfam

 PF00087; Toxin_1 

SMART

  

PROSITE

 PS00272; SNAKE_TOXIN 

PRINTS