CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021551
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 42 
Protein Synonyms/Alias
 Deubiquitinating enzyme 42; Ubiquitin thioesterase 42; Ubiquitin-specific-processing protease 42 
Gene Name
 USP42 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
327FANFTGGKIAKDVKYubiquitination[1, 2]
330FTGGKIAKDVKYPEYubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Deubiquitinating enzyme which may play an important role during spermatogenesis (By similarity). 
Sequence Annotation
 ACT_SITE 120 120 Nucleophile (By similarity).
 ACT_SITE 371 371 Proton acceptor (By similarity).
 MOD_RES 856 856 Phosphoserine.
 MOD_RES 1226 1226 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Differentiation; Hydrolase; Phosphoprotein; Polymorphism; Protease; Reference proteome; Spermatogenesis; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1324 AA 
Protein Sequence
MTIVDKASES SDPSAYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH TLSLGPVPGA 60
VVYSSSSVPD KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC LKWQQTHRVG AGLQNLGNTC 120
FANAALQCLT YTPPLANYML SHEHSKTCHA EGFCMMCTMQ AHITQALSNP GDVIKPMFVI 180
NEMRRIARHF RFGNQEDAHE FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS 240
RVKCLNCKGV SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA 300
SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE PIVYVLYAVL 360
VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL SQQAYVLFYI RSHDVKNGGE 420
LTHPTHSPGQ SSPRPVISQR VVTNKQAAPG FIGPQLPSHM IKNPPHLNGT GPLKDTPSSS 480
MSSPNGNSSV NRASPVNASA SVQNWSVNRS SVIPEHPKKQ KITISIHNKL PVRQCQSQPN 540
LHSNSLENPT KPVPSSTITN SAVQSTSNAS TMSVSSKVTK PIPRSESCSQ PVMNGKSKLN 600
SSVLVPYGAE SSEDSDEESK GLGKENGIGT IVSSHSPGQD AEDEEATPHE LQEPMTLNGA 660
NSADSDSDPK ENGLAPDGAS CQGQPALHSE NPFAKANGLP GKLMPAPLLS LPEDKILETF 720
RLSNKLKGST DEMSAPGAER GPPEDRDAEP QPGSPAAESL EEPDAAAGLS STKKAPPPRD 780
PGTPATKEGA WEAMAVAPEE PPPSAGEDIV GDTAPPDLCD PGSLTGDASP LSQDAKGMIA 840
EGPRDSALAE APEGLSPAPP ARSEEPCEQP LLVHPSGDHA RDAQDPSQSL GAPEAAERPP 900
APVLDMAPAG HPEGDAEPSP GERVEDAAAP KAPGPSPAKE KIGSLRKVDR GHYRSRRERS 960
SSGEPARESR SKTEGHRHRR RRTCPRERDR QDRHAPEHHP GHGDRLSPGE RRSLGRCSHH 1020
HSRHRSGVEL DWVRHHYTEG ERGWGREKFY PDRPRWDRCR YYHDRYALYA ARDWKPFHGG 1080
REHERAGLHE RPHKDHNRGR RGCEPARERE RHRPSSPRAG APHALAPHPD RFSHDRTALV 1140
AGDNCNLSDR FHEHENGKSR KRRHDSVENS DSHVEKKARR SEQKDPLEEP KAKKHKKSKK 1200
KKKSKDKHRD RDSRHQQDSD LSAACSDADL HRHKKKKKKK KRHSRKSEDF VKDSELHLPR 1260
VTSLETVAQF RRAQGGFPLS GGPPLEGVGP FREKTKHLRM ESRDDRCRLF EYGQGKRRYL 1320
ELGR 1324 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0016579; P:protein deubiquitination; ISS:UniProtKB.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS