CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013052
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin-conjugating enzyme E2 variant 3 
Protein Synonyms/Alias
 UEV-3; EV and lactate/malate dehydrogenase domain-containing protein 
Gene Name
 Uevld 
Gene Synonyms/Alias
 Attp; Uev3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
45SVDTYVFKDTSQKDLacetylation[1]
180GWTNHENKILNKITVubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Possible negative regulator of polyubiquitination (By similarity). 
Sequence Annotation
 DOMAIN 2 145 UEV.
 NP_BIND 191 219 NAD (By similarity).  
Keyword
 Alternative splicing; Complete proteome; NAD; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 471 AA 
Protein Sequence
MEFDCEGVRR LLGKYKFRDL TVEELKNVSV SFPHFRYSVD TYVFKDTSQK DLLNFTGTIP 60
VMYQGKTYNI PIRFWILDSH PFAPPICFLK PTANMEISVG KHVDAKGRIY LPYLQNWSHP 120
KSAIVGLIKE MIAKFQEELP LYSIPSSNEA QQVDLLAYIT KITEGVSDIN SRGWTNHENK 180
ILNKITVVGS GDLGIACTLA ISAKGIADKL LLLDLSDGMS QGTMDLDIFN LPNVEISKDL 240
SASAHSKVVI FTANSLGGSE SYLHAVQSNV DMFRALVPAL GHYSQHAVLL VASQPVEIMS 300
YVTWKLSTFP ATRVVGIGCN LDSQRLQYII TSVLKVQTSG KEVWVVGEQG ENKVCSWSGR 360
DGVLSPSSQA QLSSRAMELL KVKGQRSWSV GLSVADLVDT IINNKRKVHS VSTLAKGYYG 420
LDNEVFLSLP CILGTGGVSE VIKTKAGEDT VTGTLQASAS SIHALQQQLE L 471 
Gene Ontology
 GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006464; P:cellular protein modification process; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:InterPro. 
Interpro
 IPR001557; L-lactate/malate_DH.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR016040; NAD(P)-bd_dom.
 IPR016135; UBQ-conjugating_enzyme/RWD.
 IPR008883; UEV_N. 
Pfam
 PF02866; Ldh_1_C
 PF00056; Ldh_1_N
 PF05743; UEV 
SMART
  
PROSITE
 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2
 PS51322; UEV 
PRINTS
 PR00086; LLDHDRGNASE.