CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009872
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UBX domain-containing protein 2A 
Protein Synonyms/Alias
 UBX domain-containing protein 4 
Gene Name
 UBXN2A 
Gene Synonyms/Alias
 UBXD4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2******MKDVDNLKSubiquitination[1]
50EAQKVSSKCVSPAEQubiquitination[1]
69DVNIKLWKNGFTVNDubiquitination[1, 2, 3, 4]
94QQFLNSIKKGELPSEubiquitination[1, 2, 3, 4]
95QFLNSIKKGELPSELubiquitination[1]
189NGKRIVQKFNITHRVubiquitination[3]
205HIKDFIEKYQGSQRSubiquitination[1, 2, 3, 4]
249VIIQRLQKTASFRELubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 DOMAIN 60 124 SEP.
 DOMAIN 169 246 UBX.  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 259 AA 
Protein Sequence
MKDVDNLKSI KEEWVCETGS DNQPLGNNQQ SNCEYFVDSL FEEAQKVSSK CVSPAEQKKQ 60
VDVNIKLWKN GFTVNDDFRS YSDGASQQFL NSIKKGELPS ELQGIFDKEE VDVKVEDKKN 120
EICLSTKPVF QPFSGQGHRL GSATPKIVSK AKNIEVENKN NLSAVPLNNL EPITNIQIWL 180
ANGKRIVQKF NITHRVSHIK DFIEKYQGSQ RSPPFSLATA LPVLRLLDET LTLEEADLQN 240
AVIIQRLQKT ASFRELSEH 259 
Gene Ontology
 GO:0005801; C:cis-Golgi network; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0010468; P:regulation of gene expression; IEA:Compara.
 GO:0042176; P:regulation of protein catabolic process; IEA:Compara.
 GO:0031396; P:regulation of protein ubiquitination; IEA:Compara. 
Interpro
 IPR012989; SEP_domain.
 IPR001012; UBX. 
Pfam
 PF08059; SEP
 PF00789; UBX 
SMART
 SM00553; SEP
 SM00166; UBX 
PROSITE
 PS51399; SEP
 PS50033; UBX 
PRINTS