UniProt Accession

 ROA2_RAT; A7VJC2; A7VJC1; A7VJC3; A7VJC4 

Genbank Protein ID

 AB006815; AB006816; AB006817; AB006818 

Genbank Nucleotide ID

 BAF79675.1; BAF79676.1; BAF79677.1; BAF79678.1 

Protein Name

 Heterogeneous nuclear ribonucleoproteins A2/B1 

Protein Synonyms/Alias

 hnRNP A2/B1 

Gene Name

 Hnrnpa2b1 

Gene Synonyms/Alias

 Hnrnp; Hnrpa2b1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
3	*****MEKTLETVPL	acetylation	[1]
59	VMRDPASKRSRGFGF	acetylation	[1]
104	VAREESGKPGAHVTV	acetylation	[1]
112	PGAHVTVKKLFVGGI	acetylation	[1]
112	PGAHVTVKKLFVGGI	ubiquitination	[2]
120	KLFVGGIKEDTEEHH	acetylation	[1]
137	DYFEEYGKIDTIEII	ubiquitination	[3]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus (By similarity). 

Sequence Annotation

 DOMAIN 21 104 RRM 1.
 DOMAIN 112 191 RRM 2.
 REGION 308 347 Nuclear targeting sequence (By
 MOTIF 9 15 Nuclear localization signal (Potential).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 85 85 Phosphoserine (By similarity).
 MOD_RES 104 104 N6,N6-dimethyllysine (By similarity).
 MOD_RES 149 149 Phosphoserine (By similarity).
 MOD_RES 168 168 N6-acetyllysine (By similarity).
 MOD_RES 173 173 N6-acetyllysine (By similarity).
 MOD_RES 203 203 Dimethylated arginine; alternate (By
 MOD_RES 203 203 Omega-N-methylarginine; alternate (By
 MOD_RES 212 212 Phosphoserine (By similarity).
 MOD_RES 213 213 Dimethylated arginine; alternate (By
 MOD_RES 213 213 Omega-N-methylarginine; alternate (By
 MOD_RES 225 225 Phosphoserine (By similarity).
 MOD_RES 231 231 Phosphoserine (By similarity).
 MOD_RES 236 236 Phosphoserine (By similarity).
 MOD_RES 259 259 Phosphoserine (By similarity).
 MOD_RES 324 324 Phosphoserine (By similarity).
 MOD_RES 331 331 Phosphotyrosine (By similarity).
 MOD_RES 341 341 Phosphoserine (By similarity).
 MOD_RES 344 344 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 353 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS