| Tag | Content |
|---|
| CPLM ID | CPLM-000030 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Hyaluronan synthase 3 |
Protein Synonyms/Alias | Hyaluronate synthase 3; Hyaluronic acid synthase 3; HA synthase 3 |
Gene Name | HAS3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 78 | RRAGQALKLPSPRRG | ubiquitination | [1] | | 542 | IARRCGKKPEQYSLA | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. |
Sequence Annotation | CARBOHYD 462 462 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Complete proteome; Glycoprotein; Glycosyltransferase; Membrane; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 553 AA |
Protein Sequence | MPVQLTTALR VVGTSLFALA VLGGILAAYV TGYQFIHTEK HYLSFGLYGA ILGLHLLIQS 60
LFAFLEHRRM RRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKVVM 120
VVDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDVVRA 180
STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG 240
VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE 300
DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS 360
YFREWLYNSL WFHKHHLWMT YESVVTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG 420
IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIVVNFIG 480
LIPVSIWVAV LLGGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG 540
KKPEQYSLAF AEV 553 |
Gene Ontology | GO:0036117; C:hyaluranon cable; IDA:UniProtKB. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0050501; F:hyaluronan synthase activity; IDA:UniProtKB. GO:0005975; P:carbohydrate metabolic process; TAS:Reactome. GO:0030213; P:hyaluronan biosynthetic process; IDA:UniProtKB. GO:1900106; P:positive regulation of hyaluranon cable assembly; IDA:UniProtKB. GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |