UniProt Accession

 ABC3B_HUMAN; Q9UH17; B0QYD2; O95618; Q20WL1; Q5IFJ4; Q7Z2N3; Q7Z6D6; Q9UE74 

Genbank Protein ID

 U61083; U61084; AY743217; CT841510; AL022318; AL022318; BC053859 

Genbank Nucleotide ID

 AAD00089.1; AAD00090.1; AAW31743.1; CAJ86440.1; CAB45270.1; CAQ09851.1; AAH53859.1 

Protein Name

 DNA dC->dU-editing enzyme APOBEC-3B 

Protein Synonyms/Alias

 A3B; Phorbolin-1-related protein; Phorbolin-2/3 

Gene Name

 APOBEC3B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
320	YDYDPLYKEALQMLR	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T- cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. 

Sequence Annotation

 DOMAIN 66 100 CMP/dCMP deaminase zinc-binding 1.
 DOMAIN 253 289 CMP/dCMP deaminase zinc-binding 2.
 ACT_SITE 255 255 Proton donor (Potential).
 METAL 66 66 Zinc (By similarity).
 METAL 97 97 Zinc (By similarity).
 METAL 100 100 Zinc (By similarity).
 METAL 253 253 Zinc (By similarity).
 METAL 284 284 Zinc (By similarity).
 METAL 289 289 Zinc (By similarity).  

Keyword

 Alternative splicing; Antiviral defense; Complete proteome; Hydrolase; Immunity; Innate immunity; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; RNA-binding; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 382 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0047844; F:deoxycytidine deaminase activity; IMP:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051607; P:defense response to virus; IDA:UniProtKB.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0010529; P:negative regulation of transposition; IDA:UniProtKB. 

Interpro

 IPR016192; APOBEC/CMP_deaminase_Zn-bd.
 IPR007904; APOBEC_C.
 IPR013158; APOBEC_N.
 IPR016193; Cytidine_deaminase-like. 

Pfam

 PF05240; APOBEC_C
 PF08210; APOBEC_N 

SMART

  

PROSITE

 PS00903; CYT_DCMP_DEAMINASES 

PRINTS