CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018221
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Canalicular multispecific organic anion transporter 1 
Protein Synonyms/Alias
 ATP-binding cassette sub-family C member 2 
Gene Name
 Abcc2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
276GTSHGLTKKQSQSQDubiquitination[1]
277TSHGLTKKQSQSQDVubiquitination[1]
291VLVLEDSKKKKKKSEubiquitination[1]
491KIQVQNMKNKDKRLKubiquitination[1]
498KNKDKRLKIMNEILSubiquitination[1]
508NEILSGIKILKYFAWubiquitination[1]
520FAWEPSFKEQVNSIRubiquitination[1]
726FGSEYDEKKYQRVIEubiquitination[1]
795AVDTHVGKHIFNKVVubiquitination[1]
800VGKHIFNKVVGPNGLubiquitination[1]
811PNGLLSGKTRILVTHubiquitination[1]
840GKGTILEKGSYSDLMubiquitination[1]
855DKKGVFAKNWKTFMKubiquitination[1]
858GVFAKNWKTFMKHSGubiquitination[1]
932LKSSLKIKSVNALNKubiquitination[1]
939KSVNALNKKEEVVKGubiquitination[1]
940SVNALNKKEEVVKGQubiquitination[1]
945NKKEEVVKGQKLIKKacetylation[2]
1154RRLDSVTKSPIYSHFubiquitination[1]
1186RFLANSEKQIDTNQKubiquitination[1]
1295PPADWPKKGEIQFNNubiquitination[1]
1316PELDLVLKGITCNIKubiquitination[1]
1323KGITCNIKSTEKVGVubiquitination[1]
1327CNIKSTEKVGVVGRTubiquitination[1]
1338VGRTGAGKSSLTNCLubiquitination[1]
1398MNLDPFNKYSDEEIWubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (By similarity). 
Sequence Annotation
 DOMAIN 320 603 ABC transmembrane type-1 1.
 DOMAIN 635 859 ABC transporter 1.
 DOMAIN 977 1262 ABC transmembrane type-1 2.
 DOMAIN 1298 1532 ABC transporter 2.
 NP_BIND 669 676 ATP 1 (Potential).
 NP_BIND 1332 1339 ATP 2 (Potential).
 MOD_RES 281 281 Phosphoserine (By similarity).
 MOD_RES 876 876 Phosphoserine (By similarity).
 CARBOHYD 6 6 N-linked (GlcNAc...) (Potential).
 CARBOHYD 11 11 N-linked (GlcNAc...) (Potential).
 CARBOHYD 160 160 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1009 1009 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Complete proteome; Glycoprotein; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1543 AA 
Protein Sequence
MDEFCNSTFW NLSLLKSPEA DLPLCFEQTV LVWIPLGFLW LLAPWQLYRI YRSRTKRFAI 60
TKFYLAKQVF VVCLLILAAI DLSLALTEDT GQATIPPVKY TNPILYLCTW LLVLVIQHCR 120
QCCIQKNSWF LSMFWILSLL CGIFQFQTLI RALLQDSKSN MTYSCLFFVS YGFQIVILIL 180
SAFSESSDST HAPSATASFL SSVTFSWYDS TVLKGYKHPL TIEDVWDIEE NLKAKSLTSK 240
FKTIMTKDLQ KARQALQRRL KKSQQSPEGT SHGLTKKQSQ SQDVLVLEDS KKKKKKSEAT 300
KDFPKSWLVK ALFKTFYVVI LKSFILKLAH DILLFLNPQL LKFLIGFVKD PDSYPWVGYI 360
YAILMFSVTL IQSFFLQCYF QFCFVLGMTV RTTIIASVYK KALTLSNLAR RQYTIGETVN 420
LMSVDSQKLM DVTNYIHLLW SSVLQIALSI FFLWRELGPS ILAGVGLMVL LVPVNGVLAT 480
KIRKIQVQNM KNKDKRLKIM NEILSGIKIL KYFAWEPSFK EQVNSIRKKE LRNLLRFSQL 540
QTILIFILHL TPTLVSVITF SVYVLVDSQN VLNAEKAFTS ITLFNILRFP LAMLPMVISS 600
VIQASVSVDR LEQYLGSDDL DLSAIRHVCH FDKAVQFSEA SFTWDRDLEA TIQDVNLDIK 660
PGQLVAVVGT VGSGKSSLIS AMLGEMENVH GHITIKGSIA YVPQQAWIQN GTIKDNILFG 720
SEYDEKKYQR VIEACALLPD LEMLPGGDMA EIGEKGINLS GGQKHRVSLA RATYQDADIY 780
ILDDPLSAVD THVGKHIFNK VVGPNGLLSG KTRILVTHGI HFLPQVDEIV VLGKGTILEK 840
GSYSDLMDKK GVFAKNWKTF MKHSGPEGEA TVDNDSEEED GDCGLIPTVE EIPDDAASLT 900
MRRENSLRRT LSRSSRSGSR RGKSLKSSLK IKSVNALNKK EEVVKGQKLI KKEFVETGKV 960
KFSIYLKYLQ AVGWWSLLFI VIFYVLNYVA FIGTNLWLSA WTSDSEKQNG TDNSPSQRDM 1020
RIGVFGALGI AQGIFLLSSS LWSIYACRNA SKTLHRQLLT NILRAPMSFF DTTPTGRIVN 1080
RFAGDISTVD DTLPQTLRSW LLCFFGIVST LVMICMATPI FIIIIIPLSI LYVSVQVFYV 1140
ATSRQLRRLD SVTKSPIYSH FSETVSGLPV IRAFEHQQRF LANSEKQIDT NQKCVFSWIT 1200
SNRWLAIRLE LVGNLIVFCS ALLLVIYKNS LTGDTVGFVL SNALNITQTL NWLVRMTSEV 1260
ETNIVAVERI NEYINVDNEA PWVTDKKPPA DWPKKGEIQF NNYQVRYRPE LDLVLKGITC 1320
NIKSTEKVGV VGRTGAGKSS LTNCLFRILE SAGGQIIIDG IDIASIGLHD LRGRLTIIPQ 1380
DPILFSGNLR MNLDPFNKYS DEEIWRALEL AHLKSFVAGL QLGLLHEVTE GGDNLSIGQR 1440
QLLCLGRAVL RKSKILVLDE ATAAVDLETD SLIQTTIRNE FSQCTVITIA HRLHTIMDSD 1500
KIMVLDSGKI VEYGSPEELL SNMGPFYLMA KEAGIESVNH TEL 1543 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IDA:MGI.
 GO:0046581; C:intercellular canaliculus; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0030644; P:cellular chloride ion homeostasis; IEA:Compara.
 GO:0006855; P:drug transmembrane transport; IEA:Compara.
 GO:0015732; P:prostaglandin transport; IEA:Compara.
 GO:0046685; P:response to arsenic-containing substance; IEA:Compara.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0031427; P:response to methotrexate; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0070327; P:thyroid hormone transport; IEA:Compara. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005292; Multidrug-R_assoc.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS