CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023257
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Multiple inositol polyphosphate phosphatase 1 
Protein Synonyms/Alias
 2,3-bisphosphoglycerate 3-phosphatase; 2,3-BPG phosphatase; Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1,3,4,5)P(4) 3-phosphatase 
Gene Name
 MINPP1 
Gene Synonyms/Alias
 MIPP; UNQ900/PRO1917 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50LSPYFGTKTRYEDVNubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). 
Sequence Annotation
 MOTIF 484 487 Prevents secretion from ER (Potential).
 ACT_SITE 89 89 Potential.
 CARBOHYD 242 242 N-linked (GlcNAc...).
 CARBOHYD 481 481 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Endoplasmic reticulum; Glycoprotein; Hydrolase; Polymorphism; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 487 AA 
Protein Sequence
MLRAPGCLLR TSVAPAAALA AALLSSLARC SLLEPRDPVA SSLSPYFGTK TRYEDVNPVL 60
LSGPEAPWRD PELLEGTCTP VQLVALIRHG TRYPTVKQIR KLRQLHGLLQ ARGSRDGGAS 120
STGSRDLGAA LADWPLWYAD WMDGQLVEKG RQDMRQLALR LASLFPALFS RENYGRLRLI 180
TSSKHRCMDS SAAFLQGLWQ HYHPGLPPPD VADMEFGPPT VNDKLMRFFD HCEKFLTEVE 240
KNATALYHVE AFKTGPEMQN ILKKVAATLQ VPVNDLNADL IQVAFFTCSF DLAIKGVKSP 300
WCDVFDIDDA KVLEYLNDLK QYWKRGYGYT INSRSSCTLF QDIFQHLDKA VEQKQRSQPI 360
SSPVILQFGH AETLLPLLSL MGYFKDKEPL TAYNYKKQMH RKFRSGLIVP YASNLIFVLY 420
HCENAKTPKE QFRVQMLLNE KVLPLAYSQE TVSFYEDLKN HYKDILQSCQ TSEECELARA 480
NSTSDEL 487 
Gene Ontology
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0003993; F:acid phosphatase activity; IEA:InterPro.
 GO:0034417; F:bisphosphoglycerate 3-phosphatase activity; IDA:BHF-UCL.
 GO:0052826; F:inositol hexakisphosphate 2-phosphatase activity; IEA:EC.
 GO:0008969; F:phosphohistidine phosphatase activity; TAS:ProtInc.
 GO:0030282; P:bone mineralization; NAS:UniProtKB.
 GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
 GO:0006797; P:polyphosphate metabolic process; TAS:ProtInc. 
Interpro
 IPR000560; His_Pase_superF_clade-2.
 IPR016274; Histidine_acid_Pase_euk. 
Pfam
 PF00328; His_Phos_2 
SMART
  
PROSITE
 PS00014; ER_TARGET 
PRINTS