UniProt Accession

 TP4A2_MOUSE; O70274; Q3U1K7 

Genbank Protein ID

 AF035644; AK033092; AK045093; AK155895; BC086794; BC087551 

Genbank Nucleotide ID

 AAC15874.1; BAC28149.1; BAC32217.1; BAE33489.1; AAH86794.1; AAH87551.1 

Protein Name

 Protein tyrosine phosphatase type IVA 2 

Protein Synonyms/Alias

 Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2 

Gene Name

 Ptp4a2 

Gene Synonyms/Alias

 Prl2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
36	KFTEELKKYGVTTLV	ubiquitination	[1]
52	VCDATYDKAPVEKEG	acetylation	[2]
141	RRGAFNSKQLLYLEK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity). 

Sequence Annotation

 DOMAIN 79 145 Tyrosine-protein phosphatase.
 REGION 102 107 Phosphate binding (By similarity).
 ACT_SITE 69 69 Proton donor (By similarity).
 ACT_SITE 101 101 Phosphocysteine intermediate (By
 BINDING 107 107 Substrate (By similarity).
 MOD_RES 164 164 Cysteine methyl ester (Probable).
 LIPID 164 164 S-farnesyl cysteine.
 DISULFID 46 101 By similarity.  

Keyword

 Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Endosome; Hydrolase; Lipoprotein; Membrane; Methylation; Prenylation; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 167 AA 

Protein Sequence

Gene Ontology

 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 

Interpro

 IPR000387; Tyr/Dual-sp_Pase.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 

Pfam

 PF00102; Y_phosphatase 

SMART

  

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 

PRINTS