CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039490
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transaldolase 
Protein Synonyms/Alias
  
Gene Name
 TALDO1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
71EAIAYGRKLGGSQEDubiquitination[1, 2, 3, 4]
81GSQEDQIKNAIDKLFubiquitination[1, 4]
115DARLSFDKDAMVARAubiquitination[1, 3, 4, 5]
130RRLIELYKEAGISKDubiquitination[1, 5, 6]
136YKEAGISKDRILIKLacetylation[4]
203WHVANTDKKSYEPLEacetylation[4]
203WHVANTDKKSYEPLEubiquitination[3]
204HVANTDKKSYEPLEDubiquitination[1, 4]
215PLEDPGVKSVTKIYNubiquitination[1, 3, 5, 6]
219PGVKSVTKIYNYYKKacetylation[7]
219PGVKSVTKIYNYYKKubiquitination[1, 3, 4, 5, 6]
230YYKKFSYKTIVMGASubiquitination[5]
245FRNTGEIKALAGCDFubiquitination[4]
258DFLTISPKLLGELLQubiquitination[1]
269ELLQDNAKLVPVLSAacetylation[8]
269ELLQDNAKLVPVLSAubiquitination[3, 4, 5, 6, 9]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [8] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [9] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048
Functional Description
 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Pentose shunt; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 318 AA 
Protein Sequence
MSSSPVKRQR MESALDQLKQ FTTVVADTGD FHAIDEYKPQ DATTNPSLIL AAAQMPAYQE 60
LVEEAIAYGR KLGGSQEDQI KNAIDKLFVL FGAEILKKIP GRVSTEVDAR LSFDKDAMVA 120
RARRLIELYK EAGISKDRIL IKLSSTWEGI QAGKELEEQH GIHCNMTLLF SFAQAVACAE 180
AGVTLISPFV GRILDWHVAN TDKKSYEPLE DPGVKSVTKI YNYYKKFSYK TIVMGASFRN 240
TGEIKALAGC DFLTISPKLL GELLQDNAKL VPVLSAKPKP VTWKKSTWMR SLSVGCTTRT 300
RWLWRSSLTG SASLPLMQ 318 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004801; F:sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity; IEA:EC.
 GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR001585; Transaldolase.
 IPR004730; Transaldolase_1.
 IPR018225; Transaldolase_AS. 
Pfam
 PF00923; Transaldolase 
SMART
  
PROSITE
 PS01054; TRANSALDOLASE_1
 PS00958; TRANSALDOLASE_2 
PRINTS