UniProt Accession

 HAOX1_HUMAN; Q9UJM8; Q14CQ0; Q9UPZ0; Q9Y3I7 

Genbank Protein ID

 AF244134; AF231916; AL121739; AB024079; AL021879; BC113665; BC113667 

Genbank Nucleotide ID

 AAF63219.1; AAF40199.1; CAB57329.1; BAA82872.1; CAC34364.1; AAI13666.1; AAI13668.1 

Protein Name

 Hydroxyacid oxidase 1 

Protein Synonyms/Alias

 HAOX1; Glycolate oxidase; GOX 

Gene Name

 HAO1 

Gene Synonyms/Alias

 GOX1; HAOX1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
223	SISWEDIKWLRRLTS	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate. 

Sequence Annotation

 DOMAIN 1 365 FMN hydroxy acid dehydrogenase.
 NP_BIND 291 315 FMN (By similarity).
 NP_BIND 291 295 FMN binding.
 MOTIF 368 370 Microbody targeting signal (Potential).
 ACT_SITE 260 260 Proton acceptor.
 BINDING 26 26 Substrate.
 BINDING 108 108 FMN.
 BINDING 130 130 FMN.
 BINDING 132 132 FMN.
 BINDING 132 132 Substrate.
 BINDING 158 158 FMN.
 BINDING 167 167 Substrate.
 BINDING 236 236 FMN.
 BINDING 258 258 FMN.
 BINDING 263 263 Substrate.
 BINDING 315 315 FMN.  

Keyword

 3D-structure; Complete proteome; Flavoprotein; FMN; Oxidoreductase; Peroxisome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 370 AA 

Protein Sequence

Gene Ontology

 GO:0005782; C:peroxisomal matrix; TAS:Reactome.
 GO:0010181; F:FMN binding; IDA:UniProtKB.
 GO:0008891; F:glycolate oxidase activity; IDA:UniProtKB.
 GO:0047969; F:glyoxylate oxidase activity; TAS:Reactome.
 GO:0052853; F:long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity; IEA:EC.
 GO:0052854; F:medium-chain-(S)-2-hydroxy-acid oxidase activity; IEA:EC.
 GO:0052852; F:very-long-chain-(S)-2-hydroxy-acid oxidase activity; IEA:EC.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0001561; P:fatty acid alpha-oxidation; IDA:UniProtKB.
 GO:0046296; P:glycolate catabolic process; IDA:UniProtKB.
 GO:0046487; P:glyoxylate metabolic process; TAS:Reactome.
 GO:0006979; P:response to oxidative stress; IEA:Compara. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR012133; Alpha-hydoxy_acid_DH_FMN.
 IPR000262; FMN-dep_DH.
 IPR008259; FMN_hydac_DH_AS. 

Pfam

 PF01070; FMN_dh 

SMART

  

PROSITE

 PS00557; FMN_HYDROXY_ACID_DH_1
 PS51349; FMN_HYDROXY_ACID_DH_2 

PRINTS