UniProt Accession

 PAIP2_HUMAN; Q9BPZ3; B2RBI1; D3DQC6; Q49A06; Q9H0Y5; Q9P0Q8 

Genbank Protein ID

 AF317675; AF151052; AL136640; AK314672; CH471062; CH471062; CH471062; CH471062; BC001716; BC048106; BC062718 

Genbank Nucleotide ID

 AAK11562.1; AAF36138.1; CAB66575.1; BAG37228.1; EAW62107.1; EAW62108.1; EAW62111.1; EAW62112.1; AAH01716.1; AAH48106.1; AAH62718.1 

Protein Name

 Polyadenylate-binding protein-interacting protein 2 

Protein Synonyms/Alias

 PABP-interacting protein 2; PAIP-2; Poly(A)-binding protein-interacting protein 2 

Gene Name

 PAIP2 

Gene Synonyms/Alias

 PAIP2A; HSPC218 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
116	SNLNPNAKEFVPGVK	ubiquitination	[1, 2, 3, 4]
123	KEFVPGVKYGNI***	ubiquitination	[2, 3, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. 

Sequence Annotation

 REGION 22 75 PABPC1-interacting motif-1 (PAM1).
 REGION 105 120 PABPC1-interacting motif-2 (PAM2).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Reference proteome; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0030371; F:translation repressor activity; IDA:UniProtKB.
 GO:0045947; P:negative regulation of translational initiation; IDA:UniProtKB. 

Interpro

 IPR009818; Ataxin-2_C. 

Pfam

 PF07145; PAM2 

SMART

  

PROSITE

  

PRINTS