CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000020
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-4 complex subunit mu-1 
Protein Synonyms/Alias
 AP-4 adapter complex mu subunit; Adapter-related protein complex 4 mu-1 subunit; Mu subunit of AP-4; Mu-adaptin-related protein 2; mu-ARP2; Mu4-adaptin; mu4 
Gene Name
 AP4M1 
Gene Synonyms/Alias
 MUARP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18KGDPLIYKDFRGDSGubiquitination[1]
238TEEFCVGKSELRGYGubiquitination[2]
353ELSSPEQKAELAEGAubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal- lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP. 
Sequence Annotation
 DOMAIN 184 452 MHD.  
Keyword
 3D-structure; Coated pit; Complete proteome; Golgi apparatus; Membrane; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 453 AA 
Protein Sequence
MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMH HHGRHFIHIR 60
HSGLYLVVTT SENVSPFSLL ELLSRLATLL GDYCGSLGEG TISRNVALVY ELLDEVLDYG 120
YVQTTSTEML RNFIQTEAVV SKPFSLFDLS SVGLFGAETQ QSKVAPSSAA SRPVLSSRSD 180
QSQKNEVFLD VVERLSVLIA SNGSLLKVDV QGEIRLKSFL PSGSEMRIGL TEEFCVGKSE 240
LRGYGPGIRV DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP 300
SVQWDRGSGR LQVYLKLRCD LLSKSQALNV RLHLPLPRGV VSLSQELSSP EQKAELAEGA 360
LRWDLPRVQG GSQLSGLFQM DVPGPPGPPS HGLSTSASPL GLGPASLSFE LPRHTCSGLQ 420
VRFLRLAFRP CGNANPHKWV RHLSHSDAYV IRI 453 
Gene Ontology
 GO:0030119; C:AP-type membrane coat adaptor complex; TAS:ProtInc.
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0000138; C:Golgi trans cisterna; TAS:ProtInc.
 GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0006895; P:Golgi to endosome transport; IMP:UniProtKB.
 GO:0006886; P:intracellular protein transport; IMP:UniProtKB. 
Interpro
 IPR022775; AP_mu_sigma_su.
 IPR001392; Clathrin_mu.
 IPR008968; Clathrin_mu_C.
 IPR018240; Clathrin_mu_CS.
 IPR011012; Longin-like_dom. 
Pfam
 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 
SMART
  
PROSITE
 PS00990; CLAT_ADAPTOR_M_1
 PS00991; CLAT_ADAPTOR_M_2
 PS51072; MHD 
PRINTS
 PR00314; CLATHRINADPT.