| Tag | Content |
|---|
| CPLM ID | CPLM-010855 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin carboxyl-terminal hydrolase 3 |
Protein Synonyms/Alias | Deubiquitinating enzyme 3; Ubiquitin thioesterase 3; Ubiquitin-specific-processing protease 3 |
Gene Name | UBP3 |
Gene Synonyms/Alias | YER151C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 260 | TKSHSIPKHNEEVKT | ubiquitination | [1] | | 756 | EYELLPFKSSSGNDV | ubiquitination | [1] |
|
Reference | [1] Identification, analysis, and prediction of protein ubiquitination sites. Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM. Proteins. 2010 Feb 1;78(2):365-80. [ PMID: 19722269] |
Functional Description | Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin. Plays a role in regulation of silencing by interacting with SIR4. Also, in conjunction with BRE5, cleaves ubiquitin, leading to the subsequent mono-ubiquitination of SEC23. |
Sequence Annotation | ACT_SITE 469 469 Nucleophile (By similarity).
ACT_SITE 861 861 Proton acceptor (By similarity). |
Keyword | 3D-structure; Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 912 AA |
Protein Sequence | MNMQDANKEE SYSMYPKTSS PPPPTPTNMQ IPIYQAPLQM YGYTQAPYLY PTQIPAYSFN 60
MVNQNQPIYH QSGSPHHLPP QNNINGGSTT NNNNINKKKW HSNGITNNNG SSGNQGANSS 120
GSGMSYNKSH TYHHNYSNNH IPMMASPNSG SNAGMKKQTN SSNGNGSSAT SPSYSSYNSS 180
SQYDLYKFDV TKLKNLKENS SNLIQLPLFI NTTEAEFAAA SVQRYELNMK ALNLNSESLE 240
NSSVEKSSAH HHTKSHSIPK HNEEVKTETH GEEEDAHDKK PHASKDAHEL KKKTEVKKED 300
AKQDRNEKVI QEPQATVLPV VDKKEPEESV EENTSKTSSP SPSPPAAKSW SAIASDAIKS 360
RQASNKTVSG SMVTKTPISG TTAGVSSTNM AAATIGKSSS PLLSKQPQKK DKKYVPPSTK 420
GIEPLGSIAL RMCFDPDFIS YVLRNKDVEN KIPVHSIIPR GIINRANICF MSSVLQVLLY 480
CKPFIDVINV LSTRNTNSRV GTSSCKLLDA CLTMYKQFDK ETYEKKFLEN ADDAEKTTES 540
DAKKSSKSKS FQHCATADAV KPDEFYKTLS TIPKFKDLQW GHQEDAEEFL THLLDQLHEE 600
LISAIDGLTD NEIQNMLQSI NDEQLKVFFI RNLSRYGKAE FIKNASPRLK ELIEKYGVIN 660
DDSTEENGWH EVSGSSKRGK KTKTAAKRTV EIVPSPISKL FGGQFRSVLD IPNNKESQSI 720
TLDPFQTIQL DISDAGVNDL ETAFKKFSEY ELLPFKSSSG NDVEAKKQTF IDKLPQVLLI 780
QFKRFSFINN VNKDNAMTNY NAYNGRIEKI RKKIKYGHEL IIPEESMSSI TLKNNTSGID 840
DRRYKLTGVI YHHGVSSDGG HYTADVYHSE HNKWYRIDDV NITELEDDDV LKGGEEASDS 900
RTAYILMYQK RN 912 |
Gene Ontology | GO:0005737; C:cytoplasm; IC:SGD. GO:0003729; F:mRNA binding; IDA:SGD. GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro. GO:0004843; F:ubiquitin-specific protease activity; IDA:SGD. GO:0016579; P:protein deubiquitination; IDA:SGD. GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; IMP:SGD. GO:0047484; P:regulation of response to osmotic stress; IMP:SGD. GO:0034517; P:ribophagy; IMP:SGD. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |