CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031394
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TGF-beta receptor type-1 
Protein Synonyms/Alias
 cDNA FLJ58645, highly similar to TGF-beta receptor type-1 (EC 2.7.11.30) 
Gene Name
 TGFBR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
22FVCAPSSKTGSVTTTubiquitination[1]
144VLQESIGKGRFGEVWubiquitination[1]
163RGEEVAVKIFSSREEubiquitination[1]
322LDDSINMKHFESFKRubiquitination[1, 2, 3]
328MKHFESFKRADIYAMubiquitination[1]
380RKVVCEQKLRPNIPNubiquitination[1]
433LSQQEGIKM******ubiquitination[1, 2, 3, 4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 434 AA 
Protein Sequence
MCIAEIDLIP RDRPFVCAPS SKTGSVTTTY CCNQDHCNKI ELPTTVKSSP GLGPVELAAV 60
IAGPVCFVCI SLMLMVYICH NRTVIHHRVP NEEDPSLDRP FISEGTTLKD LIYDMTTSGS 120
GSGLPLLVQR TIARTIVLQE SIGKGRFGEV WRGKWRGEEV AVKIFSSREE RSWFREAEIY 180
QTVMLRHENI LGFIAADNKD NGTWTQLWLV SDYHEHGSLF DYLNRYTVTV EGMIKLALST 240
ASGLAHLHME IVGTQGKPAI AHRDLKSKNI LVKKNGTCCI ADLGLAVRHD SATDTIDIAP 300
NHRVGTKRYM APEVLDDSIN MKHFESFKRA DIYAMGLVFW EIARRCSIGG IHEDYQLPYY 360
DLVPSDPSVE EMRKVVCEQK LRPNIPNRWQ SCEALRVMAK IMRECWYANG AARLTALRIK 420
KTLSQLSQQE GIKM 434 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0048844; P:artery morphogenesis; IEA:Compara.
 GO:0001824; P:blastocyst development; IEA:Compara.
 GO:0030199; P:collagen fibril organization; IEA:Compara.
 GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Compara.
 GO:0043542; P:endothelial cell migration; IEA:Compara.
 GO:0008354; P:germ cell migration; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Compara.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Compara.
 GO:0048663; P:neuron fate commitment; IEA:Compara.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0060017; P:parathyroid gland development; IEA:Compara.
 GO:0060037; P:pharyngeal system development; IEA:Compara.
 GO:0051491; P:positive regulation of filopodium assembly; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0010468; P:regulation of gene expression; IEA:Compara.
 GO:0043393; P:regulation of protein binding; IEA:Compara.
 GO:0070723; P:response to cholesterol; IEA:Compara.
 GO:0048538; P:thymus development; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS.
 IPR003605; TGF_beta_rcpt_GS. 
Pfam
 PF00069; Pkinase
 PF08515; TGF_beta_GS 
SMART
 SM00467; GS 
PROSITE
 PS51256; GS
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS