UniProt Accession

 RHEB_MOUSE; Q921J2 

Genbank Protein ID

 BC012273 

Genbank Nucleotide ID

 AAH12273.1 

Protein Name

 GTP-binding protein Rheb 

Protein Synonyms/Alias

 Ras homolog enriched in brain 

Gene Name

 Rheb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
120	PIMLVGNKKDLHMER	ubiquitination	[1]
161	QTAVDVFKRIILEAE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity (By similarity). 

Sequence Annotation

 NP_BIND 16 21 GTP (By similarity).
 NP_BIND 32 38 GTP (By similarity).
 NP_BIND 149 150 GTP (By similarity).
 MOTIF 35 43 Effector region (By similarity).
 METAL 20 20 Magnesium (By similarity).
 METAL 38 38 Magnesium (By similarity).
 MOD_RES 130 130 Phosphoserine; by MAPKAPK5.
 MOD_RES 181 181 Cysteine methyl ester (By similarity).
 LIPID 181 181 S-farnesyl cysteine (By similarity).  

Keyword

 Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0030425; C:dendrite; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005681; C:spliceosomal complex; IDA:MGI.
 GO:0019003; F:GDP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0032008; P:positive regulation of TOR signaling cascade; IDA:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.