CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026166
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-dependent zinc metalloprotease FtsH 
Protein Synonyms/Alias
  
Gene Name
 ftsH 
Gene Synonyms/Alias
 TTHA0403 
Created Date
 July 27, 2013 
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 
NCBI Taxa ID
 300852 
Lysine Modification
Position
Peptide
Type
References
174VAGHEEAKRELMEVVacetylation[1]
Reference
 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 
Functional Description
 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity). 
Sequence Annotation
 NP_BIND 205 212 ATP (By similarity).
 ACT_SITE 428 428 By similarity.
 METAL 427 427 Zinc; catalytic (By similarity).
 METAL 431 431 Zinc; catalytic (By similarity).
 METAL 502 502 Zinc; catalytic (By similarity).  
Keyword
 ATP-binding; Cell cycle; Cell division; Cell inner membrane; Cell membrane; Complete proteome; Hydrolase; Membrane; Metal-binding; Metalloprotease; Nucleotide-binding; Protease; Reference proteome; Transmembrane; Transmembrane helix; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 618 AA 
Protein Sequence
MPQRFNPFNL LLLVLLGYLV YTALSGPPAP TLAYTEFREL VRQGKVAEVT LEETRITGLL 60
KAPERFPTPQ GTVQVSRRFQ VPLPPAQVQD PELLRFLEEN GVTIVTKAPS IWPQVLLYVA 120
PTLILIAFFW FFFMRAQGGA GQVMQFGQSR AKLYGKERKV NTTFKDVAGH EEAKRELMEV 180
VDFLKNPKKY LEIGAEIPKG VLLVGPPGTG KTLLARAVAG EAGVPFFSVS ASEFMEMFVG 240
VGASRVRSLF EDARRNAPSI IFIDELDSIG RKRGAGIGGG HDEREQTLNQ ILSEMDGFEK 300
DTSVIVLAAT NRPDILDPAL LRPGRFDRQV VVGLPSLEER KEILLVHMRG KPIAEDVDAL 360
ELAHLTPGFS GADLRNLVNE AALLAARNGE KRIRKEHFLK ALDKIVLGLE RSALKLSEEE 420
RRAVAYHEAG HAVVGEVLPH ADKTEKVSIV PRGMALGARW SKPEERVLVS REHLMDELAV 480
LMAGRVAEEL FTGTVTTGAQ DDFKRATGIA KRMVLDWGMG EHFKNVAWGS DSGPVFLGEE 540
IAKKKDHSEE TARLIDQDIM KILDEAYERA RKVLSTHREA VHKIAEELLR EETIPGDRVR 600
AILRETQAVE RAEDLGQE 618 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0016887; F:ATPase activity; IEA:HAMAP.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0030163; P:protein catabolic process; IEA:HAMAP.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR005936; FtsH.
 IPR027417; P-loop_NTPase.
 IPR011546; Pept_M41_FtsH_extracell.
 IPR000642; Peptidase_M41. 
Pfam
 PF00004; AAA
 PF06480; FtsH_ext
 PF01434; Peptidase_M41 
SMART
 SM00382; AAA 
PROSITE
 PS00674; AAA 
PRINTS