CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036315
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytochrome c oxidase subunit 7A2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 COX7A2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
72NKVPEKQKLFQEDDEacetylation[1]
72NKVPEKQKLFQEDDEubiquitination[2, 3, 4]
85DEIPLYLKGGVADALubiquitination[2, 3, 5]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 103 AA 
Protein Sequence
MLRNLLFHTC CPGWSAMARS QLTATSASQV QAILLPQPPK YLGLQALRQI GQRTISTASR 60
RHFKNKVPEK QKLFQEDDEI PLYLKGGVAD ALLYRATMIL TVG 103 
Gene Ontology
 GO:0005746; C:mitochondrial respiratory chain; IEA:InterPro.
 GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
 GO:0009055; F:electron carrier activity; IEA:InterPro. 
Interpro
 IPR003177; Cyt_c_oxidase_su7a. 
Pfam
 PF02238; COX7a 
SMART
  
PROSITE
  
PRINTS