UniProt Accession

 SMRC1_MOUSE; P97496; Q7TS80; Q7TT29 

Genbank Protein ID

 U85614; BC052423; BC053064 

Genbank Nucleotide ID

 AAB42085.1; AAH52423.1; AAH53064.1 

Protein Name

 SWI/SNF complex subunit SMARCC1 

Protein Synonyms/Alias

 BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI3-related protein; BAF155 

Gene Name

 Smarcc1 

Gene Synonyms/Alias

 Baf155; Srg3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
178	LIPDIDLKLANKLKD	ubiquitination	[1]
587	QMLNFPEKNKEKPID	ubiquitination	[1]
591	FPEKNKEKPIDLQNF	ubiquitination	[1]
881	ASAATKAKHLAAVEE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. 

Sequence Annotation

 DOMAIN 448 545 SWIRM.
 DOMAIN 617 668 SANT.
 MOD_RES 300 300 Phosphoserine.
 MOD_RES 309 309 Phosphoserine.
 MOD_RES 327 327 Phosphoserine.
 MOD_RES 329 329 Phosphoserine.
 MOD_RES 334 334 Phosphothreonine (By similarity).
 MOD_RES 336 336 Phosphothreonine.
 MOD_RES 344 344 N6-acetyllysine (By similarity).
 MOD_RES 345 345 N6-acetyllysine (By similarity).
 MOD_RES 349 349 Phosphoserine (By similarity).
 MOD_RES 353 353 N6-acetyllysine (By similarity).
 MOD_RES 356 356 Phosphoserine (By similarity).
 MOD_RES 358 358 N6-acetyllysine (By similarity).
 MOD_RES 397 397 Phosphothreonine (By similarity).
 MOD_RES 572 572 Phosphoserine (By similarity).
 MOD_RES 821 821 Phosphoserine (By similarity).
 MOD_RES 824 824 Phosphoserine (By similarity).
 MOD_RES 947 947 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1104 AA 

Protein Sequence

Gene Ontology

 GO:0071565; C:nBAF complex; IDA:UniProtKB.
 GO:0071564; C:npBAF complex; IDA:UniProtKB.
 GO:0016514; C:SWI/SNF complex; IDA:MGI.
 GO:0071778; C:WINAC complex; IEA:Compara.
 GO:0001741; C:XY body; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006338; P:chromatin remodeling; IEA:Compara.
 GO:0006323; P:DNA packaging; TAS:MGI.
 GO:0008286; P:insulin receptor signaling pathway; IDA:MGI.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0006337; P:nucleosome disassembly; IEA:Compara.
 GO:0009887; P:organ morphogenesis; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001357; BRCT_dom.
 IPR000953; Chromo_domain/shadow.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR007526; SWIRM.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00249; Myb_DNA-binding
 PF04433; SWIRM 

SMART

 SM00298; CHROMO
 SM00717; SANT 

PROSITE

 PS51293; SANT
 PS50934; SWIRM 

PRINTS