UniProt Accession

 NDUF5_HUMAN; Q5TEU4; A8K166; Q6GPH3; Q9H6F4 

Genbank Protein ID

 AK025977; AK289781; AL161659; AL109657; AL161659; AL109657; AL109657; AL161659; AL109657; AL161659; CH471133; BC005984; BC073158 

Genbank Nucleotide ID

 BAB15305.1; BAF82470.1; CAI15136.1; CAI15136.1; CAI15137.1; CAI15137.1; CAI22985.1; CAI22985.1; CAI22986.1; CAI22986.1; EAX10311.1; AAH05984.1; AAH73158.1 

Protein Name

 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 

Protein Synonyms/Alias

 Probable methyltransferase C20orf7, mitochondrial 

Gene Name

 NDUFAF5 

Gene Synonyms/Alias

 C20orf7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	YIAQYLNKETIGKFF	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. May have methyltransferase activity. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Disease mutation; Leigh syndrome; Membrane; Methyltransferase; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 345 AA 

Protein Sequence

Gene Ontology

 GO:0031314; C:extrinsic to mitochondrial inner membrane; IDA:UniProtKB.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB. 

Interpro

 IPR013216; Methyltransf_11. 

Pfam

 PF08241; Methyltransf_11 

SMART

  

PROSITE

  

PRINTS