CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017881
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protocadherin Fat 3 
Protein Synonyms/Alias
 FAT tumor suppressor homolog 3 
Gene Name
 Fat3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
698LAEKLLIKAKANGKLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May play a role in the interactions between neurites derived from specific subsets of neurons during development (By similarity). 
Sequence Annotation
 DOMAIN 43 157 Cadherin 1.
 DOMAIN 158 265 Cadherin 2.
 DOMAIN 263 374 Cadherin 3.
 DOMAIN 376 471 Cadherin 4.
 DOMAIN 472 577 Cadherin 5.
 DOMAIN 578 680 Cadherin 6.
 DOMAIN 726 830 Cadherin 7.
 DOMAIN 831 935 Cadherin 8.
 DOMAIN 936 1042 Cadherin 9.
 DOMAIN 1043 1147 Cadherin 10.
 DOMAIN 1148 1253 Cadherin 11.
 DOMAIN 1254 1358 Cadherin 12.
 DOMAIN 1362 1459 Cadherin 13.
 DOMAIN 1460 1565 Cadherin 14.
 DOMAIN 1566 1768 Cadherin 15.
 DOMAIN 1769 1882 Cadherin 16.
 DOMAIN 1883 1985 Cadherin 17.
 DOMAIN 1982 2083 Cadherin 18.
 DOMAIN 2084 2185 Cadherin 19.
 DOMAIN 2186 2286 Cadherin 20.
 DOMAIN 2287 2393 Cadherin 21.
 DOMAIN 2394 2495 Cadherin 22.
 DOMAIN 2496 2599 Cadherin 23.
 DOMAIN 2600 2707 Cadherin 24.
 DOMAIN 2708 2813 Cadherin 25.
 DOMAIN 2814 2923 Cadherin 26.
 DOMAIN 2924 3028 Cadherin 27.
 DOMAIN 3029 3130 Cadherin 28.
 DOMAIN 3131 3235 Cadherin 29.
 DOMAIN 3236 3340 Cadherin 30.
 DOMAIN 3341 3445 Cadherin 31.
 DOMAIN 3446 3550 Cadherin 32.
 DOMAIN 3551 3652 Cadherin 33.
 DOMAIN 3794 3832 EGF-like 1.
 DOMAIN 3834 4017 Laminin G-like.
 DOMAIN 4020 4057 EGF-like 2.
 DOMAIN 4059 4095 EGF-like 3.
 DOMAIN 4097 4133 EGF-like 4; calcium-binding (Potential).
 CARBOHYD 48 48 N-linked (GlcNAc...) (Potential).
 CARBOHYD 341 341 N-linked (GlcNAc...) (Potential).
 CARBOHYD 481 481 N-linked (GlcNAc...) (Potential).
 CARBOHYD 562 562 N-linked (GlcNAc...) (Potential).
 CARBOHYD 667 667 N-linked (GlcNAc...) (Potential).
 CARBOHYD 799 799 N-linked (GlcNAc...) (Potential).
 CARBOHYD 879 879 N-linked (GlcNAc...) (Potential).
 CARBOHYD 898 898 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1006 1006 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1367 1367 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1429 1429 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1751 1751 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1944 1944 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1993 1993 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1996 1996 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2208 2208 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2292 2292 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2331 2331 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2467 2467 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2734 2734 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3000 3000 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3201 3201 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3449 3449 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3618 3618 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3741 3741 N-linked (GlcNAc...) (Potential).
 CARBOHYD 3926 3926 N-linked (GlcNAc...) (Potential).
 DISULFID 3798 3809 By similarity.
 DISULFID 3803 3821 By similarity.
 DISULFID 3823 3831 By similarity.
 DISULFID 3984 4017 By similarity.
 DISULFID 4024 4035 By similarity.
 DISULFID 4029 4045 By similarity.
 DISULFID 4047 4056 By similarity.
 DISULFID 4063 4074 By similarity.
 DISULFID 4068 4083 By similarity.
 DISULFID 4085 4094 By similarity.
 DISULFID 4101 4112 By similarity.
 DISULFID 4106 4121 By similarity.
 DISULFID 4123 4132 By similarity.  
Keyword
 Calcium; Cell adhesion; Complete proteome; Developmental protein; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4555 AA 
Protein Sequence
MGVTMRHCID TRPPSCLIFL LLKLCATVSQ GLPGTGPLGF HFTHALYNAT VYENSAARTY 60
VNSQSRMGIT LIDLSWDIKY RIVSGDEEGF FKAEEVIIAD FCFLRIRTKG GNSAILNREI 120
QDNYLLIIKG SVRGEDLEAW TKVNIQVLDM NDLRPLFSPT TYSVTIAEST PLRTSVAQVT 180
ATDADIGSNG EFYYYFKNKV DLFSVHPTSG VISLSGRLNY DEKNRYDLEI LAVDRGMKLY 240
GNNGVSSTAK LYVHIERINE HAPIIHVVTH TPFSLDKEPT YAVVTVDDLD EGANGEIESV 300
SIVDGDPLEQ FFLAKEGKWM NEYKVKERRQ VDWESFSYGY NLTIQAKDKG SPQKFSELKT 360
VHIANPRRDS TPIKFEKDVY DISISEFSPP GVMVAIVKVN PEPLDVEYKL LPGKDAEYFK 420
INPRSGLIVT AQPLNTVKKE VYKLEVSDKE GDAKAQVTIG IEDANDHTPE FQETLYETFV 480
NESVPVGTNV LTVSASDKDK GENGYITYSI ASLNLLPFAI NQFTGVISTT EELDFESSPE 540
TYRFIVRASD WGSPYRHESE VNVTIRVGNV NDNSPLFEKV ACQGVISYDF PVGGHITAIS 600
AIDIDELELV KYKIISGNEL GFFYLNPDSG VLQLKKSLMN SGIKNGNFAL RITATDGENF 660
ADPMAINISV LHGKVSSKSF SCRETRVAQK LAEKLLIKAK ANGKLNQEDG FLDFYSINRQ 720
GPHFDKSFPS DVAVKENMPV GTNILKIKAY DADSGFNGKV LFTISDGNTD SCFNIDMETG 780
QLKVLMPMDR EHTDLYVLNI TIYDLGKPQK SSWRLLTVNV EDANDNSPVF LQDSYSVSIL 840
ESSSIGTEII QVEARDKDLG SNGEVTYSVL TDTHQFVINS STGIVYIADQ LDRESKANYS 900
LKIEARDKAE SGQQLFSVVT LKIFLDDVND CSPAFIPSSY SVKVLEDLPV GTVIAWLETQ 960
DPDLGLGGQV RYSLVNDYNG RFEIDKASGA IRLSKELDYE KQQFYNLTVR AKDKGRPVSL 1020
SSISFVEVEV VDVNENLHTP YFPDFAVVGS VKENSRIGTS VLQVTAHDED SGRDGEIQYS 1080
IRDGSGLGRF NIDDESGVIT AADILDRETT ASYWLTVYAT DRGVVPLYST IEVYIEVEDV 1140
NDNAPLTSEP IYYPVVMENS PKDVSVIQIQ AEDPDSGSNE KLTYRITSGN PQNFFAINIK 1200
TGLITTTSRK LDREQQAEHF LEVTVTDGGS SPKQSTIWVV VQVLDENDNK PQFPEKVYQI 1260
KLPERDRKKR GEPIYRAFAF DRDEGPNAEI SYSIVDGNDD GKFFIDPKTG MVSSRKQFTA 1320
GSYDILTIKA VDNGRPQKSS TARLHIEWIK KPPPSPIPLT FDEPFYNFTI MESDKVTEIV 1380
GVVSVQPANT PLWFDIIGGN FDSSFDAEKG VGTIVIAKPL DAEQRSVYNM SVEVTDGTNV 1440
AVTQVFITVL DNNDNGPEFS QPHYDVTISE DVPPDTEILQ IEATDRDEKH KLSYTIHSSI 1500
DAISMRKFRI DPSTGVLYTA ERLDHEAQDK HILNIMVRDQ EFPYRRNLAR VIVNVEDAND 1560
HSPYFTNPLY EASVFESAAL GSVVLQVTAL DKDKGENAEL IYSIEAGNTG NTFKIEPVLG 1620
IITISKEPDM TAMGQFVLSV KVTDQGSPPM SATAIVRISI SMSDNSHPKF THKDYQAEVN 1680
ENVDIGTSVI LISAISQSTL IYEVKDGNIN GVFTINPYSG VITTRRALDY EHTSSYQLII 1740
QATNMAGMAS NATVSVQVVD ENDNPPVFLF SQYSGSLSEA APINSLVRSL DNSPLVIRAT 1800
DADSNQNALL VYQIVESTAK KFFTVDSSTG AIRTIANLDH EVIAHFHFHV HVRDSGNPQL 1860
TAESPVEVNI EVTDVNDNPP VFTQAVFETV LLLPTYVGVE VLKVSATDPD SEVPPELTYS 1920
LMEGSVDHFL MDPNTGVLTI KNNNLSKDHY MLIVRVSDGK FYSTAMVTIM VKEAMDSGLH 1980
FTQSFYSTSI SENSTNITKV AIVNAVGNRL NEPLKYSILN PGNKFKIKST SGVIQTTGVP 2040
FDREEQELYE LVVEASRELD HLRVARVVVR VNIEDVNDNS PVFVGLPYYA AVQVDAEPGT 2100
LIYRVTAIDK DKGANGEVTY VLQDDYGHFE INPNSGNVIL KEAFNSDLSN IDYGVTILAK 2160
DGGTPSLSTF VELPITIVNK AMPVFDKPFY TASINEDISI NTPILSINAT SPEGQGIIYL 2220
IIDGDPFQQF NIDFDTGVLK VISPLDYEVM SVYKLTVRAS DALTGARAEV TVDLLVDDVN 2280
DNPPVFDQPT YNTTLSESSL IGTPVLQLVS TDADSGNNNL VHYQIVQDTY NSTDYFHIDS 2340
SSGLILTARM LDHELVQHCT LKVTATDNGF PSLSSEVLVQ IYISDVNDNP PVFNQLIYES 2400
YVSELAPRGH FVTCVQASDA DSSDFDRLEY SILSGNDRTS FLMDSKSGVL TLSSHRKQRM 2460
EPLYSLNVSV SDGLFTSTAQ VHIRVLGANL YSPAFSQSTY VAEVRENAAS GTKVIHVRAT 2520
DGDPGTYGQV SYSIINDFAK DRFLIDSNGQ IITTERLDRE NPLEGDISIY LRALDGGGRT 2580
TFCTVRVIVV DENDNAPQFM TLEYRASVRA DVGRGHLVTQ VQALDPDDGA NSRITYSLYS 2640
EASVSVADLL EIDPDNGWMV TKGNFNQLRN TVLSFFVKAV DGGIPVRHSL IPVYIHVLPP 2700
ETFLPSFTQS QYSFTIAEDT SIGSTIDTLR ILPNQSVRFS TVNGERPENN KENVFIIEQE 2760
TGAIKLDKRL DHEVSPAFHF KVAATIPLDK VDIVFTVDVD VKVLDLNDNK PVFETSSYET 2820
IIMEGMPVGT KLAQVRAIDT DWGANGQVTY SLHSDSHLEK VMEAFNIDSN TGWISTLKDL 2880
DHETDPTFSF FVVASDLGEA FSLSSMALVS VKVTDINDNA PVFAHEVYRG NVKESDPPGE 2940
VVAVLSTLDK DTSNINRQVS YHITGGNPRG RFALGMVQSE WKVYVKRPLD REEQDIYFLN 3000
ITASDGLFVT QAMVEVTVSD VNDNSPVCDQ VAYSASLPED IPSNKIILKV SAKDADIGSN 3060
GDIRYSLYGS GNSDFFLDPE SGELKTLALL DRERVPVYNL IARATDGGGR FCSSTVLLLL 3120
EDVNDNPPVF SSNHYTACVY ENTATKALLT RVQAVDPDVG INRKVVYSLE DSASGVFSID 3180
SSSGVIVLEQ PLDREQQSSY NISVRATDQS PGQSLSSLTS VTITVLDIND NPPVFERRDY 3240
LVTVPEDTSL GTQVLSVFAT SKDIGTNAEI TYLIRSGNEQ GKFRINPKTG GISVLEALDY 3300
EMCKRFYLVV EAKDGGTPAL STAATVSIDL TDVNDNPPRF SQDVYSAVIS EDALEGDSVI 3360
LLIAEDVDSK PNGQIRFSIV GGDRDNEFAV DPILGLVKVK KKLDRERVSG YSLLIQAVDS 3420
GIPAMSSTTT VNIDISDVND NSPVFTPANY TAVIQENKPV GTSILQLVVT DRDSFHNGPP 3480
FSFSILSGNE DEEFMLDSHG ILRSAVVFRH MESPEYLLCI QAKDSGKPQQ VSHTYIRVRV 3540
IEESTHKPTA IPLEIFIVTM EDDFPGGVIG KIHATDQDMY DVLTFALKSE QKSLFKVNSH 3600
DGKIIALGGL DSGKYVLNVS VSDGRFQVPI DVVVHVEQLV HEMLQNTVTI RFENVSPEDF 3660
VGLHMHGFRR ILRNAVLTQK QDSLRIISIQ PVVGTNQLDM LFAVEMHSSE FYKPAYLIQK 3720
LSNARRHLEN VMHIAAILEK NCSGLDCQEQ HCEQGLSLDS HALMTYSTAR ISFVCPRFYR 3780
NVRCTCNGGV CPGSNDPCVE KPCPEDMQCV GYEASRRPFL CQCPPGKLGE CSGHTSLSFA 3840
GNSYIKYRLS ENSREEDFKL ALRLRTLQSN GIIMYTRANP CMILKIVEGK LWFQLDCGSG 3900
PGILGISSRA VNDGSWHSVF LELNRNFTSL SLDDSYVERR RAPLYFQTLS TDSAIFFGAL 3960
VQADNIRSLT DTRVTQVLGG FQGCLDSVVL NHNELPLQNK RSSFAEVVGL TELKLGCVLY 4020
PDACQRSPCL HGGSCSGLPS GGYQCSCLSQ FTGTNCESEI TACFPNPCRN GGSCDPIGNT 4080
FICSCKAGLT GVTCEDDVDE CEREECENGG SCVNLFGSFF CNCTPGYVGQ YCGLRPVVVP 4140
NIQAGHSYVG KEELIGIAVV LFVIFTLIVL FIVFRKKVFR KNYSRNNITL VQDPATAALL 4200
HKSNGIPFRS LRAGDGRNVY QEVGPPQVPV RPMAYTPCFQ SDSRSNLDKG LDALGGEPQE 4260
LSTFHPESPR ILTARRGVVV CSVAPNLPAV SPCRSDCDSI RKNGWDTGSE NKGAEDTGEV 4320
TCFANSNKGS NSEVQSLNSF QSDSGDDNAY HWDTSDWMPG ARLSDIEEMP NYESQDGGAV 4380
HQGSTRELES DYYLGGYDID SEYPPPHEEE FLSQDQLPPP LPEDFPEQYE ALPPSQPTSL 4440
TGTMSPDCRR RPRFHPSQYL PPHPLPGETD LGGPPSSCDF STFAVSMNQG TEVMAPTDSV 4500
SLSLHNSRGT SSSDMSARCG FDDSEVAMSD YESAGELSLT NLHIPFVETQ HQTQV 4555 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS.
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR001791; Laminin_G. 
Pfam
 PF00028; Cadherin
 PF07645; EGF_CA
 PF02210; Laminin_G_2 
SMART
 SM00112; CA
 SM00181; EGF
 SM00179; EGF_CA
 SM00282; LamG 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS50025; LAM_G_DOMAIN 
PRINTS
 PR00205; CADHERIN.