UniProt Accession

 PIMT_HUMAN; P22061; A8K109; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03 

Genbank Protein ID

 M93008; M93009; D25545; D25546; D25547; D13892; AK289724; AL355312; AL355312; BC007501; BC008748; U49740; S73902; S73903; S73905 

Genbank Nucleotide ID

 AAA90934.1; AAA90933.1; BAA05028.1; BAA05029.1; BAA05030.1; BAA02991.1; BAF82413.1; CAH72862.1; CAH72863.1; AAH07501.1; AAH08748.1; AAB38386.1; AAC60639.2; AAC60640.1; AAC60641.2 

Protein Name

 Protein-L-isoaspartate(D-aspartate) O-methyltransferase 

Protein Synonyms/Alias

 PIMT; L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase 

Gene Name

 PCMT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MAWKSGGASHS	ubiquitination	[1]
206	QDGSIKMKPLMGVIY	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl- terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). 

Sequence Annotation

 ACT_SITE 60 60
 MOD_RES 2 2 N-acetylalanine.
 DISULFID 43 95 By similarity.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
 GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; TAS:UniProtKB.
 GO:0030091; P:protein repair; TAS:UniProtKB. 

Interpro

 IPR000682; PCMT. 

Pfam

 PF01135; PCMT 

SMART

  

PROSITE

 PS01279; PCMT 

PRINTS