CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005970
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homeobox protein Hox-D11 
Protein Synonyms/Alias
 Homeobox protein Hox-4F 
Gene Name
 HOXD11 
Gene Synonyms/Alias
 HOX4F 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
256PGEAGAEKSSSAVAPubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. 
Sequence Annotation
 DNA_BIND 266 325 Homeobox.  
Keyword
 Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 338 AA 
Protein Sequence
MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN LAPHVQPVRE 60
VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPGGGGGGA GGYAPYYAAA AAAAAAAAAA 120
EEAAMQRELL PPAGRRPDVL FKAPEPVCAA PGPPHGPAGA ASNFYSAVGR NGILPQGFDQ 180
FYEAAPGPPF AGPQPPPPPA PPQPEGAADK GDPRTGAGGG GGSPCTKATP GSEPKGAAEG 240
SGGDGEGPPG EAGAEKSSSA VAPQRSRKKR CPYTKYQIRE LEREFFFNVY INKEKRLQLS 300
RMLNLTDRQV KIWFQNRRMK EKKLNRDRLQ YFTGNPLF 338 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
 GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Compara.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Compara.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0001759; P:organ induction; IEA:Compara.
 GO:0010720; P:positive regulation of cell development; IEA:Compara.
 GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Compara.
 GO:0009954; P:proximal/distal pattern formation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR021918; DUF3528.
 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 
Pfam
 PF12045; DUF3528
 PF00046; Homeobox 
SMART
 SM00389; HOX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 
PRINTS
 PR00024; HOMEOBOX.