| Tag | Content |
|---|
| CPLM ID | CPLM-014179 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial |
Protein Synonyms/Alias | 3-hydroxyisobutyryl-coenzyme A hydrolase; HIB-CoA hydrolase; HIBYL-CoA-H |
Gene Name | Hibch |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 54 | VITLNRPKLLNALSL | acetylation | [1] | | 72 | RQIYPQLKKWERDPD | acetylation | [1] | | 73 | QIYPQLKKWERDPDT | acetylation | [1] | | 91 | IIKGAGGKAFCAGGD | acetylation | [1] | | 100 | FCAGGDIKALSEAKK | acetylation | [1] | | 220 | THFVDSEKLHVLEEE | acetylation | [1] | | 296 | PFAMEQIKVINKMSP | acetylation | [1] | | 300 | EQIKVINKMSPTSLK | acetylation | [1] | | 352 | VRAVLIDKDQTPKWK | acetylation | [1] | | 359 | KDQTPKWKPADLKDV | acetylation | [1] | | 364 | KWKPADLKDVTDEDL | acetylation | [1] | | 376 | EDLNSYFKSLGSRDL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). |
Sequence Annotation | BINDING 120 120 Substrate (By similarity).
BINDING 145 145 Substrate; via amide nitrogen (By
BINDING 168 168 Substrate (By similarity).
BINDING 176 176 Substrate (By similarity).
MOD_RES 91 91 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Alternative splicing; Branched-chain amino acid catabolism; Complete proteome; Direct protein sequencing; Hydrolase; Mitochondrion; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 385 AA |
Protein Sequence | MGQQFVWRLQ SRFSSIRRAS VILQHLRMSK HTETAEVLLE RRGCAGVITL NRPKLLNALS 60
LNMIRQIYPQ LKKWERDPDT FLIIIKGAGG KAFCAGGDIK ALSEAKKAGQ TLSQDLFREE 120
YILNNAIASC QKPYVALIDG ITMGGGVGLS VHGQFRVATE RSLFAMPETG IGLFPDVGGG 180
YFLPRLQGKL GYFLALTGFR LKGRDVHRAG IATHFVDSEK LHVLEEELLA LKSPSAEDVA 240
GVLESYHAKS KMGQDKSIIF EEHMDKINSC FSANTVEQIL ENLRQDGSPF AMEQIKVINK 300
MSPTSLKITL RQLMEGSTKT LQEVLTMEYR LTQACMEGHD FHEGVRAVLI DKDQTPKWKP 360
ADLKDVTDED LNSYFKSLGS RDLKF 385 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:EC. GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |