CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021330
UniProt Accession
Genbank Protein ID
 AB010153; Y16961; AF075428; AF075429; AF075430; AF075431; AF075432; AF075433; AF124539; AF124528; AF124529; AF124531; AF124532; AF124533; AF124534; AF124535; AF124536; AF124537; AF124538; AF124539; AF124528; AF124529; AF124531; AF124532; AF124533; AF124534; AF124535; AF124536; AF124537; AF124540; AF124528; AF124529; AF124531; AF124532; AF124533; AF124534; AF124535; AF124539; AF124530; AF124531; AF124532; AF124533; AF124534; AF124535; AF124536; AF124537; AF124538; AF124539; AF124530; AF124531; AF124532; AF124533; AF124534; AF124535; AF124536; AF124537; AF124540; AF124531; AF124533; AF124535; AF124534; AF124532; AF124530; AB016072; AB016073; AF091627; AF116770; AF116756; AF116757; AF116759; AF116760; AF116761; AF116762; AF116763; AF116764; AF116765; AF116769; AF116756; AF116757; AF116759; AF116760; AF116761; AF116762; AF116763; AF116764; AF116765; AF116766; AF116767; AF116768; AF116769; AF116756; AF116759; AF116757; AF116762; AF116764; AF116766; AF116767; AF116765; AF116763; AF116761; AF116760; AF116769; AF116756; AF116757; AF116759; AF116760; AF116761; AF116762; AF116763; AF116764; AF116765; AF116766; AF116770; AF116758; AF116760; AF116762; AF116764; AF116765; AF116763; AF116761; AF116759; AF116769; AF116758; AF116759; AF116760; AF116764; AF116766; AF116768; AF116767; AF116765; AF116763; AF116762; AF116761; AF116769; AF116758; AF116760; AF116759; AF116761; AF116763; AF116765; AF116767; AF116766; AF116764; AF116762; AF116769; AF116758; AF116760; AF116759; AF116761; AF116763; AF116765; AF116766; AF116764; AF116762; AF116771; AB042841; BC039815; AF061512; AY342152; AY341145; AY339663; AY341143; AY339664; AY341142; AY341143; AY341142; AY341144; AY342153; AY342154; AJ315499 
Genbank Nucleotide ID
 BAA32433.1; CAA76562.1; AAC62633.1; AAC62634.1; AAC62635.1; AAC62636.1; AAC62637.1; AAC62638.1; AAG45607.1; AAG45607.1; AAG45607.1; AAG45607.1; AAG45607.1; AAG45607.1; AAG45607.1; AAG45607.1; AAG45607.1; AAG45607.1; AAG45607.1; AAG45608.1; AAG45608.1; AAG45608.1; AAG45608.1; AAG45608.1; AAG45608.1; AAG45608.1; AAG45608.1; AAG45608.1; AAG45608.1; AAG45609.1; AAG45609.1; AAG45609.1; AAG45609.1; AAG45609.1; AAG45609.1; AAG45609.1; AAG45609.1; AAG45610.1; AAG45610.1; AAG45610.1; AAG45610.1; AAG45610.1; AAG45610.1; AAG45610.1; AAG45610.1; AAG45610.1; AAG45610.1; AAG45611.1; AAG45611.1; AAG45611.1; AAG45611.1; AAG45611.1; AAG45611.1; AAG45611.1; AAG45611.1; AAG45611.1; AAG45612.1; AAG45612.1; AAG45612.1; AAG45612.1; AAG45612.1; AAG45612.1; AAG45612.1; BAA32592.1; BAA32593.1; AAC43038.1; AAF43486.1; AAF43486.1; AAF43486.1; AAF43486.1; AAF43486.1; AAF43486.1; AAF43486.1; AAF43486.1; AAF43486.1; AAF43486.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43487.1; AAF43488.1; AAF43488.1; AAF43488.1; AAF43488.1; AAF43488.1; AAF43488.1; AAF43488.1; AAF43488.1; AAF43488.1; AAF43488.1; AAF43488.1; AAF43488.1; AAF43489.1; AAF43489.1; AAF43489.1; AAF43489.1; AAF43489.1; AAF43489.1; AAF43489.1; AAF43489.1; AAF43489.1; AAF43489.1; AAF43489.1; AAF43490.1; AAF43490.1; AAF43490.1; AAF43490.1; AAF43490.1; AAF43490.1; AAF43490.1; AAF43490.1; AAF43490.1; AAF43491.1; AAF43491.1; AAF43491.1; AAF43491.1; AAF43491.1; AAF43491.1; AAF43491.1; AAF43491.1; AAF43491.1; AAF43491.1; AAF43491.1; AAF43491.1; AAF43492.1; AAF43492.1; AAF43492.1; AAF43492.1; AAF43492.1; AAF43492.1; AAF43492.1; AAF43492.1; AAF43492.1; AAF43492.1; AAF43492.1; AAF43493.1; AAF43493.1; AAF43493.1; AAF43493.1; AAF43493.1; AAF43493.1; AAF43493.1; AAF43493.1; AAF43493.1; AAF43493.1; AAF61624.1; BAB20591.1; AAH39815.1; AAC24830.1; AAQ63448.1; AAQ63448.1; AAQ63449.1; AAQ63450.1; AAQ63450.1; AAQ63450.1; AAQ63451.1; AAQ63451.1; AAQ63452.1; AAQ63453.1; AAQ63454.1; CAC48053.1 
Protein Name
 Tumor protein 63 
Protein Synonyms/Alias
 p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51 
Gene Name
 TP63 
Gene Synonyms/Alias
 KET; P63; P73H; P73L; TP73L 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
588MDDLASLKIPEQFRHsumoylation[1]
676RNKQQRIKEEGE***sumoylation[1, 2, 3]
Reference
 [1] Altered sumoylation of p63alpha contributes to the split-hand/foot malformation phenotype.
 Huang YP, Wu G, Guo Z, Osada M, Fomenkov T, Park HL, Trink B, Sidransky D, Fomenkov A, Ratovitski EA.
 Cell Cycle. 2004 Dec;3(12):1587-96. [PMID: 15539951]
 [2] The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugation.
 Ghioni P, D'Alessandra Y, Mansueto G, Jaffray E, Hay RT, La Mantia G, Guerrini L.
 Cell Cycle. 2005 Jan;4(1):183-90. [PMID: 15611636]
 [3] Downregulation of DeltaNp63alpha in keratinocytes by p14ARF-mediated SUMO-conjugation and degradation.
 Vivo M, Di Costanzo A, Fortugno P, Pollice A, Calabrò V, La Mantia G.
 Cell Cycle. 2009 Nov 1;8(21):3537-43. [PMID: 19829080] 
Functional Description
 Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. 
Sequence Annotation
 DOMAIN 541 607 SAM.
 DNA_BIND 170 362
 REGION 1 107 Transcription activation.
 REGION 352 388 Interaction with HIPK2.
 REGION 394 443 Oligomerization.
 REGION 610 680 Transactivation inhibition.
 METAL 244 244 Zinc (By similarity).
 METAL 247 247 Zinc (By similarity).
 METAL 308 308 Zinc (By similarity).
 METAL 312 312 Zinc (By similarity).
 CROSSLNK 676 676 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Activator; Alternative promoter usage; Alternative splicing; Apoptosis; Complete proteome; Developmental protein; Disease mutation; DNA-binding; Ectodermal dysplasia; Isopeptide bond; Metal-binding; Notch signaling pathway; Nucleus; Reference proteome; Transcription; Transcription regulation; Ubl conjugation; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 680 AA 
Protein Sequence
MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL SPEVFQHIWD 60
FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM 120
DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 180
FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 240
VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 300
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 360
KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES 420
LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSIQSPSSYG NSSPPLNKMN SMNKLPSVSQ 480
LINPQQRNAL TPTTIPDGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP 540
PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 600
ILDHRQLHEF SSPSHLLRTP SSASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND 660
FNFDMDARRN KQQRIKEEGE 680 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0030425; C:dendrite; IBA:RefGenome.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005654; C:nucleoplasm; IDA:UniProtKB.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0003682; F:chromatin binding; IBA:RefGenome.
 GO:0003684; F:damaged DNA binding; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0002039; F:p53 binding; IBA:RefGenome.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IBA:RefGenome.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:InterPro.
 GO:0007569; P:cell aging; IEA:Compara.
 GO:0034644; P:cellular response to UV; IBA:RefGenome.
 GO:0006338; P:chromatin remodeling; IEA:Compara.
 GO:0060197; P:cloacal septation; IEA:Compara.
 GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IBA:RefGenome.
 GO:0007499; P:ectoderm and mesoderm interaction; IEA:Compara.
 GO:0030326; P:embryonic limb morphogenesis; IEA:Compara.
 GO:0002064; P:epithelial cell development; IEA:Compara.
 GO:0001736; P:establishment of planar polarity; IEA:Compara.
 GO:0048807; P:female genitalia morphogenesis; IEA:Compara.
 GO:0031069; P:hair follicle morphogenesis; IEA:Compara.
 GO:0006917; P:induction of apoptosis; TAS:ProtInc.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IBA:RefGenome.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0043616; P:keratinocyte proliferation; IEA:Compara.
 GO:0031571; P:mitotic G1 DNA damage checkpoint; IBA:RefGenome.
 GO:0010259; P:multicellular organismal aging; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0045617; P:negative regulation of keratinocyte differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
 GO:0051402; P:neuron apoptotic process; IEA:Compara.
 GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0030859; P:polarized epithelial cell differentiation; IEA:Compara.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Compara.
 GO:0045747; P:positive regulation of Notch signaling pathway; IDA:UniProtKB.
 GO:0045669; P:positive regulation of osteoblast differentiation; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0036342; P:post-anal tail morphogenesis; IEA:Compara.
 GO:0060513; P:prostatic bud formation; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IPI:UniProtKB.
 GO:0009954; P:proximal/distal pattern formation; IEA:Compara.
 GO:0043523; P:regulation of neuron apoptotic process; IBA:RefGenome.
 GO:0010332; P:response to gamma radiation; IBA:RefGenome.
 GO:0010165; P:response to X-ray; IBA:RefGenome.
 GO:0001501; P:skeletal system development; IEA:Compara.
 GO:0043589; P:skin morphogenesis; IEA:Compara.
 GO:0048745; P:smooth muscle tissue development; IEA:Compara.
 GO:0060529; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; IEA:Compara.
 GO:0048485; P:sympathetic nervous system development; IEA:Compara.
 GO:0060157; P:urinary bladder development; IEA:Compara. 
Interpro
 IPR008967; p53-like_TF_DNA-bd.
 IPR012346; p53/RUNT-type_TF_DNA-bd.
 IPR011615; p53_DNA-bd.
 IPR010991; p53_tetrameristn.
 IPR002117; p53_tumour_suppressor.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR011510; SAM_2. 
Pfam
 PF00870; P53
 PF07710; P53_tetramer
 PF07647; SAM_2 
SMART
 SM00454; SAM 
PROSITE
 PS00348; P53
 PS50105; SAM_DOMAIN 
PRINTS
 PR00386; P53SUPPRESSR.