| Tag | Content |
|---|
| CPLM ID | CPLM-012406 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable phospholipid-transporting ATPase IC |
Protein Synonyms/Alias | ATPase class I type 8B member 1 |
Gene Name | Atp8b1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 664 | CYKEIEEKEFTEWNN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. Plays a role in bile salt homeostasis. |
Sequence Annotation | ACT_SITE 454 454 4-aspartylphosphate intermediate (By
METAL 893 893 Magnesium (By similarity).
METAL 897 897 Magnesium (By similarity). |
Keyword | ATP-binding; Cell membrane; Complete proteome; Endoplasmic reticulum; Hydrolase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1251 AA |
Protein Sequence | MSTERDSETT FDEESQPNDE VVPYSDDETE DELEDQGSTV EPEQNRVNRE AEKKRETFRK 60
DCTWQVKAND RKFHEQPHFM NTKFFCIKES KYASNAIKTY KYNGFTFLPM NLFEQFKRAA 120
NFYFLILLIL QAIPQISTLA WYTTLVPLLL VLGITAIKDL VDDVARHKMD KEINNRTCEV 180
IKDGRFKIIK WKDIQVGDVI RLKKNDFIPA DILLLSSSEP NSLCYVETAE LDGETNLKFK 240
MALEITDQYL QIEDNLATFD GFIECEEPNN RLDKFTGTLF WKNQSFPLDA DKILLRGCVI 300
RNTDVCHGLV IFAGADTKIM KNSGKTRFKR TKIDYLMNYM VYTIFIVLIL VSAGLAIGHA 360
YWEAQVGNYS WYLYDGENAT PSYRGFLNFW GYIIVLNTMV PISLYVSVEV IRLGQSHFIN 420
WDLQMYYAEK DTPAKARTTT LNEQLGQIHY IFSDKTGTLT QNIMTFKKCC INGTIYGDHR 480
DASQHSHSKI ELVDFSWNTF ADGKLAFYDH YLIEQIQSGK EPEVRQFFFL LSICHTVMVD 540
RIDGQINYQA ASPDEGALVN AARNFGFAFL ARTQNTITVS ELGSERTYNV LAILDFNSDR 600
KRMSIIVRTP EGSIRLYCKG ADTVIYERLH RMNPTKQETQ DALDIFASET LRTLCLCYKE 660
IEEKEFTEWN NKFMAASVAS SNRDEALDKV YEEIEKDLIL LGATAIEDKL QDGVPETISK 720
LAKADIKIWV LTGDKKETAE NIGFACELLT EDTTICYGED INSLLHTRME NQRNRGGVSA 780
KFAPPVYEPF FPPGENRALI ITGSWLNEIL LEKKTKRSKI LKLKFPRTEE ERRMRSQSRR 840
RLEEKKEQRQ KNFVDLACEC SAVICCRVTP KQKAMVVDLV KRYKKAITLA IGDGANDVNM 900
IKTAHIGVGI SGQEGMQAVM SSDYSFAQFR YLQRLLLVHG RWSYIRMCKF LRYFFYKNFA 960
FTLVHFWYSF FNGYSAQTAY EDWFITLYNV LYSSLPVLLM GLLDQDVSDK LSLRFPGLYV 1020
VGQRDLLFNY KRFFVSLLHG VLTSMVLFFI PLGAYLQTVG QDGEAPSDYQ SFAVTVASAL 1080
VITVNFQIGL DTSYWTFVNA FSIFGSIALY FGIMFDFHSA GIHVLFPSAF QFTGTASNAL 1140
RQPYIWLTII LTVAVCLLPV VAIRFLSMTI WPSESDKIQK HRKRLKAEEQ WKRRQSVFRR 1200
GVSSRRSAYA FSHQRGYADL ISSGRSIRKK RSPLDAIIAD GTAEYRRTVE S 1251 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0031526; C:brush border membrane; IEA:Compara. GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro. GO:0000287; F:magnesium ion binding; IEA:InterPro. GO:0004012; F:phospholipid-translocating ATPase activity; IEA:EC. GO:0008206; P:bile acid metabolic process; IMP:MGI. GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |