CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003719
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc finger protein 703 
Protein Synonyms/Alias
 Zinc finger elbow-related proline domain protein 1 
Gene Name
 Znf703 
Gene Synonyms/Alias
 Zeppo1; Zfp703; Zpo1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
147ASAAAALKQLGDSPAacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. 
Sequence Annotation
 ZN_FING 460 488 C2H2-type.
 MOD_RES 2 2 N-acetylserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 594 AA 
Protein Sequence
MSDSPAGSNP RTPESSGSGG GSSSGGGGGK RPAVPAVVSL LPPADPLRQA NRLPIRVLKM 60
LSAHTGHLLH PEYLQPLSST PVSPIELDAK KSPLALLAQT CSQIGKPDPP PSSKLNSVAA 120
AAANGLGSEK DPSRSAPGAA SAAAALKQLG DSPAEDKSSF KPYSKGSGGG DSRKDSGSSS 180
VSSTTSSSSS SPGDKAGFRV PSAACPPFPP HGASVSTSSN SSSPGGSRGG SPHHSDCKNG 240
GGGAGELDKK EQEAKPSPEP AAGSRGSGGD SAHGGPEATA SGRKSEPPSA LVGAGHVAPV 300
SPYKPGHSVF PLPPSSIGYH GSIVGAYAGY PSQFVPGLDP SKSGLVGGQL SGGLGLPPGK 360
PPSSSPLTGA SPPSFLQGLC RDPYCLGGYH SASHLGGSSC STCSAHDPTG PSLKASGYPL 420
VYPGHPLQPA ALSSSAAQAA LPGHPLYTYG FMLQNEPLPH SCNWVAASGP CDKRFATSEE 480
LLSHLRTHTA LPGAEKLLAA YPGASSLGSA AAAAAAAASC HLHLPPPAAP GSPGSLSLRS 540
PHTLGLSRYH PYGKSHLSTA GGLAVPSLPT AGPYYSPYAL YGQRLASASA LGYQ 594 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0034333; P:adherens junction assembly; IDA:UniProtKB.
 GO:0060644; P:mammary gland epithelial cell differentiation; ISS:UniProtKB.
 GO:0034111; P:negative regulation of homotypic cell-cell adhesion; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
 GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IDA:UniProtKB.
 GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IDA:UniProtKB.
 GO:0060828; P:regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB.
 GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
 GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR022129; Tscrpt_rep_NocA-like.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF12402; nlz1 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS