CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038194
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dysferlin 
Protein Synonyms/Alias
  
Gene Name
 Dysf 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
214RSSAPPRKLLSDKPQubiquitination[1]
219PRKLLSDKPQDFQIRubiquitination[1]
549YAELNTGKGEGVAYRubiquitination[1]
1060LSQMEALKRHRQAEAubiquitination[1]
1549PSVIGEFKGLFKIYPubiquitination[1]
1661DLLSKDEKIGETVIDacetylation[2]
1676LENRLLSKFGARCGLubiquitination[1]
1729DRVTFQDKDYTIEEIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2083 AA 
Protein Sequence
MLCCLLARAS NLPNVKKDRR SDPVASLIFR GVKKRTKVIK NSVNPVWNEG FEWDLKGIPL 60
DQSSELLVVV KDHETMGRNR FLGEAKIPLQ EVLATPSLSA SFNAPLLDAK QQPTGASLVL 120
QVSYTPPPGA VPLFPPPASL APSPTLPDMD LVPDTGGEED TEDQGLTGDE AEPFLDQSAA 180
VGPGGPTTPR KPPSHPPPHY PGAKRKRSSA PPRKLLSDKP QDFQIRVQVI EGRQLPGVNI 240
KPVVKVTAAG QTKRTRIQKG NSPLFNETLF FNVFDSPLEL FDEPIFITVV DSRSLRTDAL 300
LGEFRMDVGT VYREPRHAYL RKWLLLSDPD DFSAGARGYL KASLCVLGPG DEAPLDKKDP 360
SEDKEDIEGN LLRPTGVALR GAHFCLKLFR AEDLPQMDDA VMDNVKQIFG FDSNKKNLVD 420
PFVEVSFAGK MLCSKILEKT ANPQWNQNIT LPAMFPSMCE KMRIRVMDWD RLTHNDTVAT 480
TYLGMSKISA TGGEIEEEPA GVLKSPQATD LDDNLGFLPT FGPCYVNLYG SPREFTGFPD 540
PYAELNTGKG EGVAYRGRVL LSLETKLVEH SEQKVEDLPA DDILRVEKYL RRRKYSLFAA 600
FYSATMLQDV DDAIQFEVSI GNYGNKFDTT CLPLASTTQY SRAVFDGCHY YYLPWGNVKP 660
VVVLSSYWED ISHRIEIQNQ LLRVADRLEA NLEQVHLALK AQCSSEDVDA LVAQLTDELL 720
ADCSQPLCDI HEIPSATHLD QYLLRLRTRH LSQIKEAALA LKLGHSELST ALEQAEDWLL 780
HLRALAEEPQ NSLPDIIIWM LQGDKRVAYQ RVPAHEVLFS RRGPSYCGRN CGKLQTIFLK 840
YPMEGMPGAR MPVQIRIKLW FGLSVDEKEF NQFAEGKLSV FAETYENQTK LALVGNWGTT 900
GLTYPKFSDV TGKIKLPKDS FRPSAGWAWA GDWFVCPEKT LLHDADAGHL SFVEEVFENQ 960
TRLPGGQWIY MSDNYTDVNG EKVLPKDDIE CPLGWKWEDE EWSTDLNRAV DEQGWEYSIT 1020
IPPDRKPKHW VPVEKMYYTH RRRRWVRLRR RDLSQMEALK RHRQAEAEGE GWEYASLFGW 1080
KFHLEYRKTD AFRRRRWRRR MEPLEKTGPA AVFALEGALG GMVDDKSEDS MSVSTLSFGV 1140
NRPTISCIFD YGNRYHLRCY LYQARDLPAM DKDSFSDPYA IVSFLHQSQK TVVEKNTLNP 1200
TWDQTLIFYE IEIFGEPASI AEHPPCIVVE LYDHDTYGAD EFMGRCICQP SLERMPRLAW 1260
FPLTRGSQPA GELLAAFELI QREKPAIHHI PGFEMHETSR ILDETEDTDL PYPPPQREAN 1320
IYMVPQNIKP ALQRTAIEIL AWGLRNMKSY QMASISSPSL VVECGGQTVQ SCVIRNLRKN 1380
PNFDVCTLFM EVMLPREDLY CPPIVVKVID NRQFGRRPVV GQCTIRSLEN FLCDPYSAES 1440
PSPQGGPDDV SLLSPGEDVL IDIDDKEPLI PVQEEEFIDW WSKFFASVGE REKCGSYLEK 1500
DFDTLKVYDT QLENVEAFGG LSDFCNTFKL YRGRTQEETD DPSVIGEFKG LFKIYPLPED 1560
PAIPMPPRQF HQLAAQGPQE CLVRIYIVRA FGLQPKDPNG KCDPYIKISI GKKSVSDQDN 1620
YIPCTLEPVF GKMFELTCTL PLEKDLKITL YDYDLLSKDE KIGETVIDLE NRLLSKFGAR 1680
CGLPQTYCVS GPNQWRDQLR PSQLLHLFCQ QHRIKAPVYR TDRVTFQDKD YTIEEIEAGR 1740
LPNPHLGPVE ERLALHVLQQ QGLVPEHVES RPLYSPLQPD IEQGKLQMWI DIFPKVLGRP 1800
GPPFNITPRK ARRFFLRCII WNTKDVILDD LSLTGEKMSD IYVKGWMVGF EEHKQKTDVH 1860
YRSLGGEGNF NWRFVFPFDY LPAEQVCAVA KKDAFWRLDK TESKIPARVV FQIWDNDKFS 1920
FDDFLGSLQL DLNRMPKPAK TAEKCSLDQL DDTFHPEWFV SLFEQKTVKG WWPCVTEEGE 1980
KKMLAGKLEM TLEIVAESEH EERPAGQGRD EPNMNPKLED PRRPDTSFLW FTSPYKTMKF 2040
ILWRRFRCAI ILFIILFILL LFLGVFVYAF PNYAAMKLVK PFR 2083 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0030315; C:T-tubule; IDA:MGI.
 GO:0001778; P:plasma membrane repair; IDA:MGI. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR012968; FerIin-domain.
 IPR012560; Ferlin_A-domain.
 IPR012561; Ferlin_B-domain.
 IPR010482; Peroxin/Dysferlin.
 IPR006614; Peroxin/Ferlin. 
Pfam
 PF00168; C2
 PF08165; FerA
 PF08150; FerB
 PF08151; FerI
 PF06398; Pex24p 
SMART
 SM00239; C2
 SM00694; DysFC
 SM00693; DysFN 
PROSITE
 PS50004; C2 
PRINTS