| Tag | Content |
|---|
| CPLM ID | CPLM-009952 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Signal transducing adapter molecule 1 |
Protein Synonyms/Alias | STAM-1 |
Gene Name | Stam |
Gene Synonyms/Alias | Stam1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 276 | TAEPEMIKTEKKTVQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). |
Sequence Annotation | DOMAIN 16 143 VHS.
REPEAT 171 190 UIM.
DOMAIN 210 269 SH3.
DOMAIN 369 386 ITAM.
MOD_RES 156 156 Phosphoserine (By similarity).
MOD_RES 198 198 Phosphotyrosine (By similarity).
MOD_RES 381 381 Phosphotyrosine (By similarity).
MOD_RES 384 384 Phosphotyrosine (By similarity). |
Keyword | Complete proteome; Cytoplasm; Endosome; Membrane; Phosphoprotein; Protein transport; Reference proteome; SH3 domain; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 548 AA |
Protein Sequence | MPLFATNPFD QDVEKATSEL NTAEDWGLIL DICDKVGQSR TGPKDCLRSI MRRVNHKDPH 60
VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSNVLNKG HPKVCEKLKA LMVEWTDEFK 120
NDPQLSLISA MIKNLKEQGV TFPAIGSQAA EQAKASPALV AKDPGTVATK KEEEDLAKAI 180
ELSLKEQRQQ SAPVSTLYPS TSNLLTNHQH EGRKVRAVYD FEAAEDNELT FKAGEIITVL 240
DDSDPNWWKG ETHQGVGLFP SNFVTADLTA EPEMIKTEKK TVQFNDDVQI ETIEPEPEPA 300
FIDEDKMDQL LQMLQSTDPS DNQPDLPELL HLEAMCHQMG PLIDEKLEDI DRKHSELSEL 360
NVKVMEALSL YTKLMNEDPM YSMYAKLQSQ QYYLQSSAVS ASQVYPGPAQ SGTYLVAGSA 420
QMTHLQSYSL PPEQLSSISQ GAVPSSANQA LPSQQTQASY PNAMVSSVQG NSYPSQASIY 480
SPPAAAAAAA AAAVVPVPVP ADVTIYQNAG PTMSQVPNYT LTSSTLPQTG GSQQPPQPQQ 540
AYSQKALL 548 |
Gene Ontology | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. GO:0006886; P:intracellular protein transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |