UniProt Accession

 RL25_YEAST; P04456; D6W1U1 

Genbank Protein ID

 U41293; X01014; Z74869; BK006948 

Genbank Nucleotide ID

 AAC49465.1; CAA25506.1; CAA99146.1; DAA10657.1 

Protein Name

 60S ribosomal protein L25 

Protein Synonyms/Alias

 RP16L; YL25; YP42' 

Gene Name

 RPL25 

Gene Synonyms/Alias

 YOL127W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
45	LKLARAPKYASKAVP	acetylation	[1]
49	RAPKYASKAVPHYNR	acetylation	[1]
61	YNRLDSYKVIEQPIT	acetylation	[1]
61	YNRLDSYKVIEQPIT	sumoylation	[2]
61	YNRLDSYKVIEQPIT	ubiquitination	[3]
74	ITSETAMKKVEDGNI	acetylation	[1]
74	ITSETAMKKVEDGNI	ubiquitination	[3, 4]
75	TSETAMKKVEDGNIL	ubiquitination	[3]
100	YQIKKAVKELYEVDV	acetylation	[1]
100	YQIKKAVKELYEVDV	ubiquitination	[3]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] A proteomic strategy for gaining insights into protein sumoylation in yeast.
 Denison C, Rudner AD, Gerber SA, Bakalarski CE, Moazed D, Gygi SP.
 Mol Cell Proteomics. 2005 Mar;4(3):246-54. [PMID: 15542864]
 [3] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [4] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 This protein binds to a specific region on the 26S rRNA. 

Sequence Annotation

 CROSSLNK 61 61 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; TAS:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IDA:SGD.
 GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; TAS:SGD.
 GO:0002181; P:cytoplasmic translation; TAS:SGD.
 GO:0000027; P:ribosomal large subunit assembly; IMP:SGD. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR012678; Ribosomal_L23/L15e_core_dom.
 IPR001014; Ribosomal_L23/L25_CS.
 IPR005633; Ribosomal_L23/L25_N.
 IPR013025; Ribosomal_L25/23. 

Pfam

 PF00276; Ribosomal_L23
 PF03939; Ribosomal_L23eN 

SMART

  

PROSITE

 PS00050; RIBOSOMAL_L23 

PRINTS