CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018692
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium/glucose cotransporter 2 
Protein Synonyms/Alias
 Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2 
Gene Name
 Slc5a2 
Gene Synonyms/Alias
 Sglt2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
350CVVPEVCKRVCGTEVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules (By similarity). 
Sequence Annotation
 CARBOHYD 248 248 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Sugar transport; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 670 AA 
Protein Sequence
MEQHVEAGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV GGYFLAGRSM 60
VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA LFVVLLLGWL FVPVYLTAGV 120
ITMPQYLRKR FGGHRIRLYL SVLSLFLYIF TKISVDMFSG AVFIQQALGW NIYASVIALL 180
GITMIYTVTG GLAALMYTDT VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAMTSLTV 240
SKDPSVGNIS STCYQPRPDS YHLLRDPVTG DLPWPALLLG LTIVSGWYWC SDQVIVQRCL 300
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK RVCGTEVGCS 360
NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS TLFTMDIYTR LRPRAGDKEL 420
LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL FDYIQSVSSY LAPPVSAVFV LALFVPRVNE 480
KGAFWGLVGG LLMGLARLIP EFFFGSGSCV RPSACPALFC RVHYLYFAII LFICSGILTL 540
GISLCTAPIP QKHLHRLVFS LRHSKEERED LDADELEGPA PAPVQNGGQE CAMEMEEVQS 600
PAPGLLRRCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPRWARV VNLNALLMMT 660
VAVFLWGFYA 670 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
 GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
 GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. 
Interpro
 IPR001734; Na/solute_symporter.
 IPR018212; Na/solute_symporter_CS.
 IPR019900; Na/solute_symporter_subgr. 
Pfam
 PF00474; SSF 
SMART
  
PROSITE
 PS00456; NA_SOLUT_SYMP_1
 PS00457; NA_SOLUT_SYMP_2
 PS50283; NA_SOLUT_SYMP_3 
PRINTS