UniProt Accession

 RAD52_YEAST; P06778; D6VZE2 

Genbank Protein ID

 M10249; Z46659; AY693144; BK006946 

Genbank Nucleotide ID

 AAA50352.1; CAA86623.1; AAT93163.1; DAA09866.1 

Protein Name

 DNA repair and recombination protein RAD52 

Protein Synonyms/Alias

  

Gene Name

 RAD52 

Gene Synonyms/Alias

 YML032C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
10	EIMDMDEKKPVFGNH	sumoylation	[1, 2]
11	IMDMDEKKPVFGNHS	sumoylation	[1, 2]
126	AAFERAKKSAVTDAL	sumoylation	[3]
200	EQQQYPNKRRQLTKV	sumoylation	[4]
220	DSTKNLVKIENTVSR	sumoylation	[1, 2]

Reference

 [1] Control of Rad52 recombination activity by double-strand break-induced SUMO modification.
 Sacher M, Pfander B, Hoege C, Jentsch S.
 Nat Cell Biol. 2006 Nov;8(11):1284-90. [PMID: 17013376]
 [2] Rad52 SUMOylation affects the efficiency of the DNA repair.
 Altmannova V, Eckert-Boulet N, Arneric M, Kolesar P, Chaloupkova R, Damborsky J, Sung P, Zhao X, Lisby M, Krejci L.
 Nucleic Acids Res. 2010 Aug;38(14):4708-21. [PMID: 20371517]
 [3] Rad52 sumoylation and its involvement in the efficient induction of homologous recombination.
 Ohuchi T, Seki M, Branzei D, Maeda D, Ui A, Ogiwara H, Tada S, Enomoto T.
 DNA Repair (Amst). 2008 Jun 1;7(6):879-89. [PMID: 18396468]
 [4] Nuclear localization of Rad52 is pre-requisite for its sumoylation.
 Ohuchi T, Seki M, Enomoto T.
 Biochem Biophys Res Commun. 2008 Jul 18;372(1):126-30. [PMID: 18482582] 

Functional Description

 Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single- stranded DNA and by stimulation of the RAD51 recombinase. 

Sequence Annotation

  

Keyword

 Alternative initiation; Complete proteome; DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 471 AA 

Protein Sequence

Gene Ontology

 GO:0000228; C:nuclear chromosome; IDA:SGD.
 GO:0000150; F:recombinase activity; IDA:SGD.
 GO:0000733; P:DNA strand renaturation; IDA:SGD.
 GO:0000727; P:double-strand break repair via break-induced replication; TAS:SGD.
 GO:0045002; P:double-strand break repair via single-strand annealing; IGI:SGD.
 GO:0000707; P:meiotic DNA recombinase assembly; TAS:SGD.
 GO:0000709; P:meiotic joint molecule formation; IMP:SGD.
 GO:0006301; P:postreplication repair; IMP:SGD.
 GO:0000722; P:telomere maintenance via recombination; IMP:SGD. 

Interpro

 IPR004585; DNA_recomb/repair_Rad52.
 IPR007232; Rad52_Rad22. 

Pfam

 PF04098; Rad52_Rad22 

SMART

  

PROSITE

  

PRINTS