CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005914
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exportin-1 
Protein Synonyms/Alias
 Chromosome region maintenance protein 1; Karyopherin-124 
Gene Name
 CRM1 
Gene Synonyms/Alias
 KAP124; XPO1; YGR218W; G8514 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
50DNPDAWQKADQILQFubiquitination[1]
263LTEVSNLKIPQDNDLubiquitination[1]
466SDTIQLYKSEREVLVacetylation[2]
861EHRVEFYKLLKVINEacetylation[2]
864VEFYKLLKVINEKSFacetylation[2]
1029YKDLVVFKGTLRDFLacetylation[2]
1078AKIGGLLKPSELDD*ubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Receptor for the leucine-rich nuclear export signal (NES). 
Sequence Annotation
 DOMAIN 34 100 Importin N-terminal.
 MOD_RES 1080 1080 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1084 AA 
Protein Sequence
MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK ADQILQFSTN 60
PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS MCQDDEVFKT QKNLINKSDL 120
TLVQILKQEW PQNWPEFIPE LIGSSSSSVN VCENNMIVLK LLSEEVFDFS AEQMTQAKAL 180
HLKNSMSKEF EQIFKLCFQV LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST 240
KFMTSPDTRA ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT 300
YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL SKIEERELFK 360
TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST GSGALNPEYM KRFPLKKHIY 420
EEICSQLRLV IIENMVRPEE VLVVENDEGE IVREFVKESD TIQLYKSERE VLVYLTHLNV 480
IDTEEIMISK LARQIDGSEW SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV 540
KKRGKDNKAV VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI 600
KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI IISEERSVAE 660
RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA NIIKTNVAVC TSMGADFYPQ 720
LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA TKTPKVRGLR TIKKEILKLV ETYISKARNL 780
DDVVKVLVEP LLNAVLEDYM NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC 840
TLDMINKDFT EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV 900
EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS GFSKQALLLM 960
KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS NAFPHLTSEQ IASFLSALTK 1020
QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL FAEDKENALM EQNRLEREKA AKIGGLLKPS 1080
ELDD 1084 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0000776; C:kinetochore; IDA:SGD.
 GO:0005643; C:nuclear pore; IEA:InterPro.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005816; C:spindle pole body; IDA:SGD.
 GO:0008565; F:protein transporter activity; IDA:SGD.
 GO:0006406; P:mRNA export from nucleus; IMP:SGD.
 GO:0006611; P:protein export from nucleus; IMP:SGD.
 GO:0034501; P:protein localization to kinetochore; IGI:SGD.
 GO:0000055; P:ribosomal large subunit export from nucleus; IMP:SGD. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR014877; CRM1_C_dom.
 IPR013598; Exportin-1/Importin-b-like.
 IPR001494; Importin-beta_N. 
Pfam
 PF08767; CRM1_C
 PF03810; IBN_N
 PF08389; Xpo1 
SMART
 SM01102; CRM1_C
 SM00913; IBN_N 
PROSITE
 PS50166; IMPORTIN_B_NT 
PRINTS