CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010800
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium channel subunit beta-1 
Protein Synonyms/Alias
  
Gene Name
 Scn1b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
62TEWTFRQKGTEEFVKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. 
Sequence Annotation
 DOMAIN 22 150 Ig-like C2-type.
 CARBOHYD 93 93 N-linked (GlcNAc...) (Potential).
 CARBOHYD 110 110 N-linked (GlcNAc...) (Potential).
 CARBOHYD 114 114 N-linked (GlcNAc...) (Potential).
 CARBOHYD 135 135 N-linked (GlcNAc...) (Potential).
 DISULFID 40 121  
Keyword
 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Ion channel; Ion transport; Membrane; Reference proteome; Signal; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 218 AA 
Protein Sequence
MGTLLALVVG AVLVSSAWGG CVEVDSETEA VYGMTFKILC ISCKRRSETT AETFTEWTFR 60
QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD LQDLSIFITN VTYNHSGDYE 120
CHVYRLLFFD NYEHNTSVVK KIHLEVVDKA NRDMASIVSE IMMYVLIVVL TIWLVAEMVY 180
CYKKIAAATE AAAQENASEY LAITSESKEN CTGVQVAE 218 
Gene Ontology
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0033268; C:node of Ranvier; IEA:Compara.
 GO:0030315; C:T-tubule; IEA:Compara.
 GO:0001518; C:voltage-gated sodium channel complex; IDA:RGD.
 GO:0019871; F:sodium channel inhibitor activity; IEA:Compara.
 GO:0017080; F:sodium channel regulator activity; IDA:RGD.
 GO:0086062; F:voltage-gated sodium channel activity involved in regulation of Purkinje myocyte action potential; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0021966; P:corticospinal neuron axon guidance; IEA:Compara.
 GO:0019227; P:neuronal action potential propagation; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0010765; P:positive regulation of sodium ion transport; IEA:Compara.
 GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Compara.
 GO:0086002; P:regulation of cardiac muscle cell action potential involved in contraction; IEA:Compara.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Compara.
 GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IEA:Compara.
 GO:0002028; P:regulation of sodium ion transport; IDA:RGD.
 GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Compara.
 GO:0046684; P:response to pyrethroid; IDA:RGD. 
Interpro
 IPR013783; Ig-like_fold.
 IPR013151; Immunoglobulin.
 IPR027098; Na_channel_b1/b3. 
Pfam
 PF00047; ig 
SMART
  
PROSITE
 PS50835; IG_LIKE 
PRINTS